RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using raloxifene and tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells.

PURPOSE: Randomizeddouble-blindedclinical trial to compare the effectiveness of raloxifene with that of tamoxifen in preventing breast cancer in postmenopausal women.

Condition	Treatment or Intervention	Phase
Breast Cancer	Drug: raloxifene  Drug: tamoxifen  Procedure: cancer prevention intervention  Procedure: chemoprevention of cancer	Phase III

Further Study Details: 

OBJECTIVES:

• Determine whether raloxifene is more or less effective than tamoxifen in significantly reducing the incidence rate of invasive breast cancer in postmenopausal women.
• Evaluate the effects of tamoxifen and raloxifene on the incidence of intraductal carcinoma in situ, lobular carcinoma in situ, endometrial cancer, ischemic heart disease, fractures of the hip and spine, or Colles' fractures of the wrist in these participants.
• Evaluate the toxic effects of these regimens in these participants.
• Determine the effect of these regimens on the quality of life of these participants (at selected centers). (Quality of life evaluation closed to accrual effective 5/31/01.)

OUTLINE: This is a randomized, double-blind study. Participants are stratified by age (35 to 49 vs 50 to 59 vs over 59), race (black vs white vs other), history of lobular carcinoma in situ (yes vs no), prior hysterectomy (yes vs no), and estimated absolute risk of invasive breast cancer within 5 years (using the Gail model)(less than 2.0 vs 2.0-2.9 vs 3.0-4.9 vs 5.0 or greater). Participants are randomized to 1 of 2 arms.

• Arm I: Participants receive oral tamoxifen plus placebo daily for 5 years.
• Arm II: Participants receive oral raloxifene plus placebo daily for 5 years. Quality of life is assessed (at selected centers) at baseline and at 6, 12, 18, 24, 30, 36, 42, 48, 54, 60, and 72 months. (Quality of life evaluation closed to accrual effective 5/31/01.)

Participants are followed annually after 5 years.

PROJECTED ACCRUAL: Approximately 19,000 participants will be accrued for this study within 5 years.

Ages Eligible for Study:  35 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Postmenopausal women at increased risk for developing invasive breast cancer, who meet one of the following criteria:
• At least 12 months since spontaneous menstrual bleeding
• Prior documented hysterectomy and bilateral salpingo-oophorectomy
• At least 55 years of age with prior hysterectomy with or without oophorectomy
• Age 35 to 54 with a prior hysterectomy without oophorectomy OR with a status of ovaries unknown with documented follicle-stimulating hormone level demonstrating elevation in postmenopausal range
• Histologically confirmed lobular carcinoma in situ treated by local excision only OR at least 1.66% probability of invasive breast cancer within 5 years using Breast Cancer Risk Assessment Profile
• No clinical evidence of malignancy on physical exam within the past 180 days
• No evidence of suspicious or malignant disease on bilateral mammogram within the past year
• No bilateral or unilateral prophylactic mastectomy
• No prior invasive breast cancer or intraductal carcinoma in situ
• Hormone receptor status:
• Not specified

PATIENT CHARACTERISTICS: Age:

• 35 and over

Sex:

• Female

Menopausal status:

• See Disease Characteristics

Performance status:

• No restricted normal activity for a significant portion of each day

Life expectancy:

• At least 10 years

Hematopoietic:

• Granulocyte count at least 1,500/mm^3
• Complete blood count and differential normal
• Platelet count normal

Hepatic:

• SGOT or SGPT normal
• Bilirubin normal
• Alkaline phosphatase normal

Renal:

• Creatinine normal

Cardiovascular:

• No cerebral vascular accident, transient ischemic attack, atrial fibrillation, or uncontrolled hypertension
• No deep vein thrombosis

Pulmonary:

• No pulmonary embolus

Other:

• No other prior malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• No concurrent nonmalignant disease that would preclude administration of tamoxifen or raloxifene
• No clinical depression, psychiatric condition, or addictive disorder
• No uncontrolled diabetes

PRIOR CONCURRENT THERAPY: Biologic therapy:

• Not specified

Chemotherapy:

• Not specified

Endocrine therapy:

• At least 3 months since prior estrogen or progesterone replacement therapy, oral contraceptives, androgens, luteinizing hormone-releasing hormone analogs, prolactin inhibitors, or antiandrogens
• At least 3 months since prior tamoxifen, raloxifene, or other selective estrogen-receptor modulators of less than 3 months duration
• Concurrent Estring allowed

Radiotherapy:

• No prior breast radiotherapy

Surgery:

• See Disease Characteristics

Other:

• No prior systemic adjuvant therapy for breast cancer
• No other participation in a cancer prevention or osteoporosis prevention study involving pharmacologic intervention(s)
• NSABP-P-1 patients who received placebo are eligible
• No concurrent warfarin or cholestyramine
• Concurrent calcitonin or nonhormonal medication (e.g., cholecalciferol, fluoride, or bisphosphonates) allowed

Alabama
      Comprehensive Cancer Institute, Huntsville,  Alabama,  35801,  United States
      MBCCOP - Gulf Coast, Mobile,  Alabama,  36688,  United States
Alaska
      Providence Alaska Medical Center, Anchorage,  Alaska,  99519-6604,  United States
Arizona
      Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson,  Arizona,  85724,  United States
      CCOP - Mayo Clinic Scottsdale Oncology Program, Scottsdale,  Arizona,  85259-5404,  United States
      CCOP - Western Regional, Arizona, Phoenix,  Arizona,  85006-2726,  United States
Arkansas
      Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States
      Breast Associates, Fayetteville,  Arkansas,  72703,  United States
      Northeast Arkansas Clinic, Jonesboro,  Arkansas,  72401,  United States
      Surgical Associates, Fort Smith,  Arkansas,  72917,  United States
California
      Alta Bates Comprehensive Cancer Center, Berkeley,  California,  94704,  United States
      Breast Health Center, Oceanside,  California,  92056,  United States
      California Pacific Medical Center - California Campus, San Francisco,  California,  94118-1618,  United States
      Cancer Center of Santa Barbara, Santa Barbara,  California,  93105,  United States
      CCOP - Santa Rosa Memorial Hospital, Santa Rosa,  California,  95403,  United States
      Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center, Los Angeles,  California,  90033,  United States
      Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center, Orange,  California,  92868,  United States
      City of Hope Comprehensive Cancer Center, Duarte,  California,  91010-3000,  United States
      Comprehensive Cancer Centers of the Desert, Palm Springs,  California,  92262,  United States
      Corona Regional Medical Center, Corona,  California,  92882-3400,  United States
      Crosson Cancer Center at St. Jude Medical Center, Fullerton,  California,  92835,  United States
      Enloe Cancer Center at Enloe Medical Center, Chico,  California,  95926,  United States
      Glendale Memorial Hospital Comprehensive Cancer Center, Glendale,  California,  91204,  United States
      Hemet Valley Medical Center, Hemet,  California,  92543,  United States
      Huntington Cancer Center at Huntington Hospital, Pasadena,  California,  91109-7013,  United States
      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1781,  United States
      Kaiser Foundation Hospital - West Los Angeles, Los Angeles,  California,  90034,  United States
      Kaiser Permanente Medical Cener - Woodland Hills, Woodland Hills,  California,  91365-4084,  United States
      Kaiser Permanente Medical Center - Anaheim/Orange County, Anaheim,  California,  92805,  United States
      Kaiser Permanente Medical Center - Baldwin Park, Baldwin Park,  California,  91706,  United States
      Kaiser Permanente Medical Center - Bellflower, Bellflower,  California,  90706,  United States
      Kaiser Permanente Medical Center - Fontana, Fontana,  California,  92335,  United States
      Kaiser Permanente Medical Center - Harbor City, Harbor City,  California,  90710,  United States
      Kaiser Permanente Medical Center - Los Angeles, Los Angeles,  California,  90027,  United States
      Kaiser Permanente Medical Center - Riverside, Riverside,  California,  92505,  United States
      Kaiser Permanente Medical Center - Vallejo, Vallejo,  California,  94589,  United States
      Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego,  California,  92120,  United States
      Kaiser Permanente Medical Group, Panorama City,  California,  91402,  United States
      Leavey Cancer Center at Northridge Hospital Medical Center, Northridge,  California,  91328,  United States
      Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States
      Marin General Hospital Cancer Institute, Greenbrae,  California,  94904,  United States
      Mills-Peninsula Health Services, Burlingame,  California,  94010,  United States
      Mission Cancer Center at Mission Hospital, Mission Viejo,  California,  92691,  United States
      Mount Diablo Medical Center, Concord,  California,  94524-4110,  United States
      Naval Medical Center - San Diego, San Diego,  California,  92134-3202,  United States
      North Bay Cancer Center, Fairfield,  California,  94533,  United States
      North Valley Breast Clinic, Redding,  California,  96001,  United States
      Oncology/Hematology Associates, Granada Hills,  California,  91344,  United States
      Pacific Shores Medical Group Comprehensive Hematology–Oncology Services - Long Beach, Long Beach,  California,  90813,  United States
      Palo Alto Medical Foundation, Palo Alto,  California,  95819-5156,  United States
      Providence Saint Joseph Medical Center - Burbank, Burbank,  California,  91505,  United States
      Rebecca and John Moores UCSD Cancer Center, La Jolla,  California,  92093-0658,  United States
      Santa Clarita Valley Cancer Center - UCLA, Valencia,  California,  91355,  United States
      Scripps Memorial Hospitals-Stevens Cancer Center - Encinitas, Encinitas,  California,  92024,  United States
      St. Joseph Hospital Regional Cancer Center - Orange, Orange,  California,  92868-3849,  United States
      St. Vincent Medical Center - Los Angeles, Los Angeles,  California,  90057-1901,  United States
      Stanford Cancer Center at Stanford University Medical Center, Stanford,  California,  94305-5408,  United States
      Sutter Breast Cancer Group, Sacramento,  California,  95819-5156,  United States
      Sutter Gould Medical Foundation, Modesto,  California,  95353,  United States
      Sutter Roseville Medical Center, Roseville,  California,  95661,  United States
      Todd Cancer Institute at Long Beach Memorial Medical Center, Long Beach,  California,  90801-1428,  United States
      Torrance Memorial Medical Center, Torrance,  California,  90505,  United States
      UCSF Comprehensive Cancer Center, San Francisco,  California,  94143-0128,  United States
      USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles,  California,  90033-0804,  United States
      Valley Tumor Medical Group, Lancaster,  California,  93534,  United States
      Ventura Hematology - Oncology Specialists - Oxnard, Oxnard,  California,  93030,  United States
      Wilshire Oncology Medical Group, Incorporated - Pomona, Pomona,  California,  91767-3021,  United States
Colorado
      CCOP - Colorado Cancer Research Program, Incorporated, Denver,  Colorado,  80209-5031,  United States
      Penrose Cancer Center, Colorado Springs,  Colorado,  80933,  United States
      Poudre Valley Hospital, Fort Collins,  Colorado,  80524,  United States
      St. Mary-Corwin Regional Medical Center, Pueblo,  Colorado,  81004,  United States
Connecticut
      Eastern Connecticut Hematology and Oncology Associates, Norwich,  Connecticut,  06360,  United States
      Hartford Hospital, Hartford,  Connecticut,  06102-5037,  United States
      Hematology Oncology, P.C., Stamford,  Connecticut,  06902,  United States
      Hospital of St. Raphael, New Haven,  Connecticut,  06511,  United States
      Lawrence and Memorial Hospital, New London,  Connecticut,  06320,  United States
      Manchester Memorial Hospital, Manchester,  Connecticut,  06040-4188,  United States
      Midstate Medical Center, Meriden,  Connecticut,  06451,  United States
      New Britain General Hospital, New Britain,  Connecticut,  06050,  United States
      Northwestern Connecticut Oncology-Hematology Associates, Torrington,  Connecticut,  06790,  United States
      St. Francis Hospital and Medical Center, Hartford,  Connecticut,  06105,  United States
      University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center, Farmington,  Connecticut,  06360-7106,  United States
      Windham Community Memorial Hospital, Williamantic,  Connecticut,  06226,  United States
      Yale Comprehensive Cancer Center, New Haven,  Connecticut,  06520-8028,  United States
Delaware
      Beebe Medical Center, Lewes,  Delaware,  19958,  United States
      CCOP - Christiana Care Health Services, Wilmington,  Delaware,  19899,  United States
      Nanticoke Memorial Hospital, Seaford,  Delaware,  19973,  United States
District of Columbia
      Lombardi Cancer Center at Georgetown University Medical Center, Washington,  District of Columbia,  20007,  United States
      Providence Hospital, Washington,  District of Columbia,  20017,  United States
      Washington Hospital Center, Washington,  District of Columbia,  20010,  United States
Florida
      Baptist Regional Cancer Institute - Jacksonville, Jacksonville,  Florida,  32207,  United States
      Cancer Research Network Inc., Plantation,  Florida,  33324,  United States
      CCOP - Mount Sinai Medical Center, Miami Beach,  Florida,  33140,  United States
      Clinical Research Center of South Florida, Stuart,  Florida,  34996,  United States
      Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter,  Florida,  33458,  United States
      Florida Hospital Medical Center, Orlando,  Florida,  32803-1273,  United States
      H. Lee Moffitt Cancer Center and Research Institute, Tampa,  Florida,  33612-9497,  United States
      JFK Medical Center, Atlantis,  Florida,  33462,  United States
      Lakeland Regional Cancer Center at Lakeland Regional Medical Center, Lakeland,  Florida,  33804,  United States
      Mayo Clinic - Jacksonville, Jacksonville,  Florida,  32224,  United States
      MD Anderson Cancer Center Orlando, Orlando,  Florida,  32806,  United States
      Palm Beach Cancer Institute, West Palm Beach,  Florida,  33401,  United States
      St. Vincent's Medical Center, Jacksonville,  Florida,  32203,  United States
      University of Miami Sylvester Cancer Center, Miami,  Florida,  33136,  United States
      Watson Clinic, Lakeland,  Florida,  33804-5000,  United States
      West Florida Regional Medical Center, Pensacola,  Florida,  32514-6088,  United States
Georgia
      Cancer Care and Research Pavilion at St. Joseph's/Candler, Savannah,  Georgia,  31405-6013,  United States
      CCOP - Atlanta Regional, Atlanta,  Georgia,  30342-1701,  United States
      Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah,  Georgia,  31403-3089,  United States
      Medical College of Georgia, Augusta,  Georgia,  30912,  United States
Hawaii
      MBCCOP - Hawaii, Honolulu,  Hawaii,  96813,  United States
Idaho
      North Idaho Cancer Center, Coeur D Alene,  Idaho,  83814,  United States
Illinois
      Advocate Christ Medical Center, Oak Lawn,  Illinois,  60453,  United States
      Advocate South Suburban Hospital, Hazel Crest,  Illinois,  60429,  United States
      Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood,  Illinois,  60153,  United States
      CCOP - Carle Cancer Center, Urbana,  Illinois,  61801,  United States
      CCOP - Central Illinois, Decatur,  Illinois,  62526,  United States
      CCOP - Evanston, Evanston,  Illinois,  60201,  United States
      CCOP - Illinois Oncology Research Association, Peoria,  Illinois,  61602,  United States
      Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago,  Illinois,  60657,  United States
      Edward H. Kaplan MD and Associates, Skokie,  Illinois,  60076,  United States
      Edward Hospital Cancer Center, Naperville,  Illinois,  60540-7499,  United States
      Evanston Northwestern Health Care - Highland Park Hospital, Highland Park,  Illinois,  60035-2497,  United States
      Hinsdale Hematology Oncology Associates, Hinsdale,  Illinois,  60521,  United States
      Ingalls Memorial Hospital, Harvey,  Illinois,  60426,  United States
      John H. Stroger, Jr. Hospital of Cook County, Chicago,  Illinois,  60612-9985,  United States
      Joliet Oncology Hematology Associates, Limited - Joliet, Joliet,  Illinois,  60435,  United States
      Lutheran General Cancer Care Center, Park Ridge,  Illinois,  60068,  United States
      MBCCOP - University of Illinois at Chicago, Chicago,  Illinois,  60612-7323,  United States
      Memorial Medical Center, Springfield,  Illinois,  62781,  United States
      Mid-Illinois Hematology-Oncology Associates, Normal,  Illinois,  61761,  United States
      Northwest Community Hospital, Arlington Heights,  Illinois,  60005,  United States
      Northwestern Memorial Hospital, Chicago,  Illinois,  60611,  United States
      Our Lady of the Resurrection Medical Center, Chicago,  Illinois,  60634,  United States
      Resurrection Medical Center, Chicago,  Illinois,  60631,  United States
      Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago,  Illinois,  60611-3013,  United States
      Rockford Clinic, Rockford,  Illinois,  61103,  United States
      Rush Cancer Institute at Rush University Medical Center, Chicago,  Illinois,  60612,  United States
      Rush Copley Medical Center, Aurora,  Illinois,  60504-4206,  United States
      Saint Anthony Medical Center, Rockford,  Illinois,  61108,  United States
      Saint James Hospital and Health Centers Comprehensive Cancer Institute, Olympia Fields,  Illinois,  60461,  United States
      Sherman Hospital, Elgin,  Illinois,  60120-2198,  United States
      St. Francis Hospital, Evanston,  Illinois,  60202,  United States
      St. John's Hospital, Springfield,  Illinois,  62769,  United States
      Swedish-American Regional Cancer Center, Rockford,  Illinois,  61104-2315,  United States
      Trinity Medical Center - West, Rock Island,  Illinois,  61201,  United States
      University of Chicago Cancer Research Center, Chicago,  Illinois,  60637-1470,  United States
Indiana
      Ball Memorial Hospital Cancer Center, Muncie,  Indiana,  47303-3499,  United States
      CCOP - Northern Indiana CR Consortium, South Bend,  Indiana,  46601,  United States
      Center for Cancer Care at Goshen Health System, Goshen,  Indiana,  46526,  United States
      Community Hospital, Munster,  Indiana,  46321,  United States
      Indiana Community Cancer Care, Incorporated, Indianapolis,  Indiana,  46202,  United States
      Indiana Regional Cancer Center, Indianapolis,  Indiana,  46256,  United States
      Methodist Cancer Center at Methodist Hospital, Indianapolis,  Indiana,  46206-1367,  United States
      Oncology Institute of Greater Lafayette, Lafayette,  Indiana,  47904,  United States
      Saint Anthony Memorial Health Centers, Michigan City,  Indiana,  46360,  United States
      St. Vincent Hospital and Health Care Center, Indianapolis,  Indiana,  46260,  United States
Iowa
      CCOP - Cedar Rapids Oncology Project, Cedar Rapids,  Iowa,  52403-1206,  United States
      CCOP - Iowa Oncology Research Association, Des Moines,  Iowa,  50309-1016,  United States
      Cedar Valley Medical Specialists, P.C., Waterloo,  Iowa,  50701,  United States
      Genesis Regional Cancer Center at Genesis Medical Center, Davenport,  Iowa,  52803,  United States
      Holden Comprehensive Cancer Center at University of Iowa, Iowa City,  Iowa,  52242-1009,  United States
      Jennie Edmundson Memorial Hospital, Council Bluffs,  Iowa,  51503,  United States
      McFarland Clinic, P.C., Ames,  Iowa,  50010,  United States
      Medical Associates, Clinton,  Iowa,  52732-5031,  United States
      Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City,  Iowa,  50401,  United States
      Ottumwa Regional Health Center, Ottumwa,  Iowa,  52501,  United States
      Siouxland Hematology-Oncology, Sioux City,  Iowa,  51101-1733,  United States
      Wendt Regional Cancer Center of Finley Hospital, Dubuque,  Iowa,  52001,  United States
Kansas
      CCOP - Wichita, Wichita,  Kansas,  67214-3882,  United States
      Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City,  Kansas,  66160-7357,  United States
Kentucky
      Baptist Hospital East - Louisville, Louisville,  Kentucky,  40207,  United States
      Central Baptist Hospital, Lexington,  Kentucky,  40503,  United States
      HCA Kings Daughters Memorial Hospital, Frankfort,  Kentucky,  40601,  United States
      James Graham Brown Cancer Center at University of Louisville, Louisville,  Kentucky,  40202,  United States
      King's Daughters Medical Center, Ashland,  Kentucky,  41101,  United States
      Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington,  Kentucky,  40536-0093,  United States
      Norton Healthcare Cancer Center, Louisville,  Kentucky,  40202-5070,  United States
      St. Elizabeth Medical Center, Edgewood,  Kentucky,  41017,  United States
Louisiana
      Baton Rouge General Medical Center, Baton Rouge,  Louisiana,  70821-2511,  United States
      Cancer Care Specialists, Houma,  Louisiana,  70360,  United States
      Cancer Treatment Center at Christus Schumpert St. Mary Place, Shreveport,  Louisiana,  71101,  United States
      CCOP - Ochsner, New Orleans,  Louisiana,  70121,  United States
      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States
      Ochsner Clinic of Baton Rouge, Baton Rouge,  Louisiana,  70809,  United States
      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70112,  United States
Maine
      Eastern Maine Medical Center, Bangor,  Maine,  04401,  United States
      Goodall Hospital, Sanford,  Maine,  04073,  United States
      Maine Center for Cancer Medicine and Blood Disorders - Scarborough, Scarborough,  Maine,  04074,  United States
Maryland
      Anne Arundel Medical Center, Annapolis,  Maryland,  21401,  United States
      Franklin Square Hospital Center, Baltimore,  Maryland,  21237,  United States
      Frederick Memorial Hospital Regional Cancer Therapy Center, Frederick,  Maryland,  21701,  United States
      Greater Baltimore Medical Center and Cancer Center, Baltimore,  Maryland,  21204,  United States
      Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore,  Maryland,  21201,  United States
      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21231-2410,  United States
      Suburban Hospital, Bethesda,  Maryland,  20814,  United States
Massachusetts
      Baystate Regional Cancer Program at Baystate Medical Center, Springfield,  Massachusetts,  01199,  United States
      Berkshire Physicians and Surgeons, P.C., Pittsfield,  Massachusetts,  01201,  United States
      Beth Israel Deaconess Medical Center, Boston,  Massachusetts,  02215,  United States
      Cancer Research Center at Boston Medical Center, Boston,  Massachusetts,  02118,  United States
      Caritas Norwood Hospital, Norfolk,  Massachusetts,  02062,  United States
      Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston,  Massachusetts,  02115,  United States
      Harvard Vanguard Medical Associates - Kenmore, Boston,  Massachusetts,  02215,  United States
      Jordan Hospital Club Cancer Center, Plymouth,  Massachusetts,  02360,  United States
      Lahey Clinic Medical Center - Burlington, Burlington,  Massachusetts,  01805,  United States
      Massachusetts General Hospital Cancer Center, Boston,  Massachusetts,  02114,  United States
      NSMC Cancer Center, Peabody,  Massachusetts,  01960,  United States
      Saint Anne's Hospital, Fall River,  Massachusetts,  02721,  United States
      University of Massachusetts Memorial Medical Center - University Campus, Worcester,  Massachusetts,  01655,  United States
Michigan
      Barbara Ann Karmanos Cancer Institute, Detroit,  Michigan,  48201-1379,  United States
      Battle Creek Health System, Battle Creek,  Michigan,  49016,  United States
      Bay Diagnostic Center for Women, Bay City,  Michigan,  48708,  United States
      Blue Water Oncology PC, Port Huron, Port Huron,  Michigan,  48060,  United States
      CCOP - Beaumont, Royal Oak,  Michigan,  48073-6769,  United States
      CCOP - Grand Rapids, Grand Rapids,  Michigan,  49503,  United States
      CCOP - Kalamazoo, Kalamazoo,  Michigan,  49007-3731,  United States
      CCOP - Michigan Cancer Research Consortium, Ann Arbor,  Michigan,  48106,  United States
      Center for Hematology/Oncology, Jackson,  Michigan,  49201,  United States
      Community Cancer Care Specialist, Mount Clemens,  Michigan,  48043,  United States
      Community Health Center of Branch County, Coldwater,  Michigan,  49036,  United States
      Flint Hematology Oncology, Flint,  Michigan,  48532,  United States
      Genesys Regional Medical Center, Grand Blanc,  Michigan,  48439-8066,  United States
      Hickman Cancer Center at Bixby Medical Center, Adrian,  Michigan,  49221,  United States
      Holland Community Hospital, Holland,  Michigan,  49423,  United States
      Hurley Medical Center, Flint,  Michigan,  48503,  United States
      Josephine Ford Cancer Center at Henry Ford Hospital, Detroit,  Michigan,  48202,  United States
      Lapeer Regional Hospital, Lapeer,  Michigan,  48446,  United States
      Marquette General Hospital, Marquette,  Michigan,  49855,  United States
      Memorial Healthcare, Owosso,  Michigan,  48867,  United States
      Mercy Memorial Hospital, Corporation, Monroe,  Michigan,  48161-0067,  United States
      Michigan State University Department of Surgery, Lansing,  Michigan,  48912,  United States
      Munson Medical Center, Traverse City,  Michigan,  49684,  United States
      Oakwood Hospital and Medical Center, Dearborn,  Michigan,  48123-2500,  United States
      Providence Cancer Institute at Providence Hospital, Southfield,  Michigan,  48075-9975,  United States
      Saint Mary's Seton Cancer Institute, Saginaw,  Michigan,  48601,  United States
      St. John Hospital and Medical Center, Detroit,  Michigan,  48236,  United States
      St. John Macomb Hospital, Warren,  Michigan,  48093-3494,  United States
      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0752,  United States
Minnesota
      CCOP - Duluth, Duluth,  Minnesota,  55805,  United States
      CCOP - Metro-Minnesota, Saint Louis Park,  Minnesota,  55416,  United States
      Hennepin County Medical Center - Minneapolis, Minneapolis,  Minnesota,  55415,  United States
      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905,  United States
      Minnesota Cooperative Group Program, Minneapolis,  Minnesota,  55407,  United States
      Rice Memorial Hospital, Willmar,  Minnesota,  56201,  United States
      St. Luke's Medical Clinic, Duluth,  Minnesota,  55805,  United States
      University of Minnesota, Minneapolis,  Minnesota,  55455,  United States
Mississippi
      Coast Oncology/Hematology, P.L.L.C., Biloxi,  Mississippi,  39530-4239,  United States
      Hattiesburg Clinic, P.A., Hattiesburg,  Mississippi,  39401,  United States
      Jackson Oncology Associates, PLLC, Jackson,  Mississippi,  39202,  United States
      Keesler Medical Center - Keesler Air Force Base, Keesler AFB,  Mississippi,  39534-2576,  United States
      Mid Delta Family Practice, Cleveland,  Mississippi,  38732,  United States
      North Mississippi Hematology and Oncology Associates, Limited, Tupelo,  Mississippi,  38801,  United States
Missouri
      CCOP - Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Kansas City, Kansas City,  Missouri,  64131,  United States
      CCOP - St. Louis-Cape Girardeau, Saint Louis,  Missouri,  63141,  United States
      Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia,  Missouri,  65203,  United States
      Freeman Cancer Institute at Freeman Health System, Joplin,  Missouri,  64803-2644,  United States
      Midwest Hematology Oncology Group, Inc., Saint Louis,  Missouri,  63109,  United States
      Missouri Baptist Cancer Center, Saint Louis,  Missouri,  63131,  United States
      Missouri Cancer Care, P.C. - St. Charles, St. Charles,  Missouri,  63301,  United States
      Ozarks Medical Center, West Plains,  Missouri,  65775,  United States
      Phelps County Regional Medical Center, Rolla,  Missouri,  65401,  United States
      Saint Luke's Hospital, Chesterfield,  Missouri,  63017,  United States
      Siteman Cancer Center, Saint Louis,  Missouri,  63110,  United States
      St. John's Regional Health Center, Springfield,  Missouri,  65804,  United States
      St. John's Regional Medical Center, Joplin,  Missouri,  64804,  United States
Montana
      CCOP - Montana Cancer Consortium, Billings,  Montana,  59101,  United States
      Kalispell Regional Medical Center, Kalispell,  Montana,  59901,  United States
      Montana Cancer Institute - Benefis Healthcare, Great Falls,  Montana,  59405,  United States
Nebraska
      Alegent Health - Immanuel Medical Center, Omaha,  Nebraska,  68122,  United States
      Bergan Mercy Medical Center, Omaha,  Nebraska,  68124,  United States
      Cancer Center at the Good Samaritan Health Systems, Kearney,  Nebraska,  68848-1990,  United States
      Cancer Resource Center - Lincoln, Lincoln,  Nebraska,  68510-4844,  United States
      Creighton University Medical Center, Omaha,  Nebraska,  68131-2197,  United States
      Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha,  Nebraska,  68114,  United States
      Saint Francis Medical Center, Grand Island,  Nebraska,  68802,  United States
Nevada
      CCOP - Southern Nevada Cancer Research Foundation, Las Vegas,  Nevada,  89106,  United States
New Hampshire
      New Hampshire Oncology-Hematology, PA - Hooksett, Hooksett,  New Hampshire,  03106,  United States
      Southern New Hampshire Medical Center, Nashua,  New Hampshire,  03061,  United States
New Jersey
      Atlantic City Medical Center, Pomona,  New Jersey,  08240,  United States
      Booker Cancer Center at Riverview Medical Center, Red Bank,  New Jersey,  07701,  United States
      Cancer Institute of New Jersey, New Brunswick,  New Jersey,  08903,  United States
      Capital Health System at Mercer, Trenton,  New Jersey,  08607,  United States
      CCOP - Northern New Jersey, Hackensack,  New Jersey,  07601,  United States
      Community Medical Center, Toms River,  New Jersey,  08755,  United States
      Cooper Cancer Institute, Camden,  New Jersey,  08103,  United States
      Englewood Hospital and Medical Center, Englewood,  New Jersey,  07631,  United States
      Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital, Mount Holly,  New Jersey,  08060,  United States
      Hunterdon Regional Cancer Center, Flemington,  New Jersey,  08822,  United States
      Monmouth Medical Center, Long Branch,  New Jersey,  07740-6395,  United States
      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112,  United States
      Somerset Medical Center, Somerville,  New Jersey,  08876,  United States
      South Jersey Regional Cancer Center, Millville,  New Jersey,  08332,  United States
      St. Barnabas Medical Center, Livingston,  New Jersey,  07039,  United States
      Underwood Memorial Hospital, Woodbury,  New Jersey,  08096,  United States
      Valley Hospital, Ridgewood,  New Jersey,  07450,  United States
      Warren Hospital, Phillipsburg,  New Jersey,  08865,  United States
New Mexico
      Hematology-Oncology Associates, PC, Albuquerque,  New Mexico,  87102,  United States
      Lovelace Medical Center at Lovelace Sandia Health System, Albuquerque,  New Mexico,  87108,  United States
      New Mexico Cancer Care Associates, Santa Fe,  New Mexico,  87505-7670,  United States
      New Mexico Oncology-Hematology Consultants, Limited, Albuquerque,  New Mexico,  87109,  United States
      University of New Mexico Cancer Research and Treatment Center, Albuquerque,  New Mexico,  87131,  United States
New York
      Albert Einstein Clinical Cancer Center, Bronx,  New York,  10461,  United States
      CCOP - North Shore University Hospital, Manhasset,  New York,  11030,  United States
      CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse,  New York,  13217,  United States
      Charles R. Wood Foundation Cancer Center at Glens Falls Hospital, Glens Falls,  New York,  12801,  United States
      Comprehensive Cancer Center at Our Lady of Mercy Medical Center, Bronx,  New York,  10466,  United States
      Genesee Surgical Associates, Rochester,  New York,  14607,  United States
      Gynecologic Oncology Associates, Rochester,  New York,  14620,  United States
      Herbert Irving Comprehensive Cancer Center at Columbia University, New York,  New York,  10032,  United States
      James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester,  New York,  14642,  United States
      Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital, Cooperstown,  New York,  13326-1394,  United States
      Memorial Sloan-Kettering Cancer Center, New York,  New York,  10021,  United States
      New York Oncology Hematology, P.C. - Albany Regional Cancer Center, Albany,  New York,  12208,  United States
      New York Oncology Hematology, P.C. - Latham, Latham,  New York,  12110-0610,  United States
      NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York,  New York,  10016,  United States
      Queens Cancer Center of Queens Hospital, Jamaica,  New York,  11432,  United States
      Roswell Park Cancer Institute, Buffalo,  New York,  14263-0001,  United States
      Saint Vincent Catholic Medical Center of New York, New York,  New York,  10011,  United States
      St. Francis Hospital and Health Centers, Poughkeepsie,  New York,  12601,  United States
      University Hospital - Stony Brook, Stony Brook,  New York,  11794-8174,  United States
      University Hospital at State University of New York - Upstate Medical University, Syracuse,  New York,  13210,  United States
      Vassar Brothers Medical Center, Poughkeepsie,  New York,  12601,  United States
North Carolina
      Blumenthal Cancer Center at Carolinas Medical Center, Charlotte,  North Carolina,  28232-2861,  United States
      Cancer Center at Iredell Memorial Hospital, Statesville,  North Carolina,  28687-1828,  United States
      Cape Fear Valley Health System, Fayetteville,  North Carolina,  28302-2000,  United States
      CCOP - Southeast Cancer Control Consortium, Winston Salem,  North Carolina,  27104-4241,  United States
      Comprehensive Cancer Center at Wake Forest University, Winston Salem,  North Carolina,  27157-1082,  United States
      Cornerstone Surgery, High Point,  North Carolina,  27262,  United States
      Duke Comprehensive Cancer Center, Durham,  North Carolina,  27710,  United States
      Forsyth Medical Center, Winston Salem,  North Carolina,  27103,  United States
      Gaston Hematology and Oncology, Gastonia,  North Carolina,  28054,  United States
      Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina, Greenville,  North Carolina,  27858-4354,  United States
      Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill,  North Carolina,  27599-7295,  United States
      Mission Hospitals, Asheville,  North Carolina,  28801,  United States
      Moses Cone Regional Cancer Center at Wesley Long Community Hospital, Greensboro,  North Carolina,  27403-1199,  United States
      New Hanover Regional Medical Center, Wilmington,  North Carolina,  28402-9000,  United States
      Pardee Memorial Hospital, Hendersonville,  North Carolina,  28791,  United States
      Presbyterian Healthcare, Charlotte,  North Carolina,  28233-3549,  United States
      Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer Center, Raleigh,  North Carolina,  27607,  United States
      Southeastern Medical Oncology Center, Goldsboro,  North Carolina,  27534,  United States
North Dakota
      CCOP - Merit Care Hospital, Fargo,  North Dakota,  58122,  United States
      Quain & Ramstad Clinic, Bismarck,  North Dakota,  58501,  United States
Ohio
      Akron General Medical Center, Akron,  Ohio,  44302,  United States
      Arthur G. James Cancer Hospital - Ohio State University, Columbus,  Ohio,  43210-1240,  United States
   

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Publications

Wickerham DL. Tamoxifen versus raloxifene in the prevention of breast cancer. Eur J Cancer. 2002 Nov;38 Suppl 6:S20-1. No abstract available.

Source: ClinicalTrials.gov
Cache Date: April 9, 2005