A Study of Fluconazole in the Prevention of Fungal Infections in HIV-Infected Patients Living in Areas Where Fungal Infections Are Common - Article
Clinical Trial: A Study of Fluconazole in the Prevention of Fungal Infections in HIV-Infected Patients Living in Areas Where Fungal Infections Are Common
This study has been completed.
To compare the efficacy of fluconazole versus placebo in preventing the development of active coccidioidomycosis and other systemic fungal infections among HIV-infected patients with CD4 lymphocyte counts < 250 cells/mm3 who are living in the coccidioidal endemic area.
|Condition||Treatment or Intervention|
| Drug: Fluconazole |
MedlinePlus related topics: AIDS; Fungal Infections
Study Type: Interventional
Study Design: Treatment, Parallel Assignment, Efficacy Study
Official Title: A Double-Blind, Placebo-Controlled Study of Fluconazole in the Prevention of Active Coccidioidomycosis and Other Systemic Fungal Infections in HIV-Infected Patients Living in the Coccidioidal Endemic Area
Ages Eligible for Study: 13 Years and above, Genders Eligible for Study: Both
Patients must have:
- Documented HIV infection.
- CD4 count < 250 cells/mm3.
- No active coccidioidomycosis or other fungal disease requiring systemic antifungal therapy.
- Residence in area considered to be endemic for Coccidioides immitis.
- Consent of parent or guardian if under legal age of consent.
Co-existing Condition: Patients with the following symptoms or conditions are excluded:
- Unable to take oral medication.
- Positive serum cryptococcal antigen. Concurrent Medication: Excluded:
- Systemic antifungal therapy. Patients with the following prior conditions are excluded: History of hypersensitivity to azole or imidazole compounds.
Prior Medication: Excluded:
- Systemic antifungal agents within 2 weeks prior to study entry.
McDowell Clinic, Phoenix, Arizona, 85006, United States
Tucson Veterans Administration Med Ctr, Tucson, Arizona, 85723, United States
Dr Lawrence Cone, Rancho Mirage, California, 92270, United States
Record last reviewed: April 1996
Last Updated: October 13, 2004
Record first received: November 2, 1999
ClinicalTrials.gov Identifier: NCT00002325
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08
Cache Date: April 9, 2005
- Birds, Infections from (Centers for Disease Control and Prevention)