Not Signed In -
Systemic Lupus Erythematosus |
Sle |
Clinical Trial: Genetic Studies of Lupus
This study is currently recruiting patients.
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Purpose
The Lupus Genetic Linkage Study and Lupus Multiplex Registry & Repository are working to find the genes that cause systemic lupus erythematosus (SLE, or lupus). The study is enrolling families of all ethnic backgrounds from the United States, Canada, Puerto Rico, and the Virgin Islands that have two or more living members diagnosed with SLE.
| Condition |
|---|
| Systemic Lupus Erythematosus |
MedlinePlus related topics: Lupus
Study Type: Observational
Study Design: Natural History, Longitudinal, Defined Population, Retrospective/Prospective Study
Official Title: Lupus Multiplex Registry & Repository
Study start: October 1995
SLE is an often crippling and potentially fatal autoimmune disease that is nine times more prevalent in women than in men, and four times more likely to affect African American females than Caucasian females. It is suspected that a genetic predisposition along with environmental factors contribute to the clinical manifestation of SLE.
The Lupus Multiplex Registry & Repository is the largest repository of its kind in North America. In addition to the research done on site, the Repository serves as a national resource for scientists interested in conducting research on SLE and lupus multiplex families. Data, serum samples, and DNA samples are available to researchers. By collecting pedigrees in which two or more living individuals have been diagnosed with SLE, the study is utilizing the genetic link between the affected family members to discover disease-associated genes.
Records will be requested from the patients' treating physicians to document various lupus symptoms and related problems. One-time blood samples will be collected from the patients as well as from certain family members and an unrelated volunteer. There is no cost to participate and the study pays for sample draws and shipping.
Eligibility
Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
Inclusion Criteria:
- Families in which one or more living members have been diagnosed with systemic lupus erythematosus
- Live in the United States, Canada, Puerto Rico, or the Virgin Islands
Location and Contact Information
Oklahoma
Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, United States; Recruiting
John B. Harley, MD, PhD, Principal Investigator, Member & Program Head, Arthritis and Immunology Research Program; Oklahoma Medical Research Foundation
More Information
Lupus Multiplex Registry & Repository Webpage: For potential participants and researchers
Publications that report results of this study
Harley JB, Moser KL, Gaffney PM, Behrens TW. The genetics of human systemic lupus erythematosus. Curr Opin Immunol. 1998 Dec;10(6):690-6. Review.
Moser KL, Gray-McGuire C, Kelly J, Asundi N, Yu H, Bruner GR, Mange M, Hogue R, Neas BR, Harley JB. Confirmation of genetic linkage between human systemic lupus erythematosus and chromosome 1q41. Arthritis Rheum. 1999 Sep;42(9):1902-7.
Rao S, Olson JM, Moser KL, Gray-McGuire C, Bruner GR, Kelly J, Harley JB. Linkage analysis of human systemic lupus erythematosus-related traits: a principal component approach. Arthritis Rheum. 2001 Dec;44(12):2807-18.
Tsao BP, Grossman JM, Riemekasten G, Strong N, Kalsi J, Wallace DJ, Chen CJ, Lau CS, Ginzler EM, Goldstein R, Kalunian KC, Harley JB, Arnett FC, Hahn BH, Cantor RM. Familiality and co-occurrence of clinical features of systemic lupus erythematosus. Arthritis Rheum. 2002 Oct;46(10):2678-85.
Namjou B, Nath SK, Kilpatrick J, Kelly JA, Reid J, James JA, Harley JB. Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3. Arthritis Rheum. 2002 Nov;46(11):2937-45.
Scofield RH, Bruner GR, Kelly JA, Kilpatrick J, Bacino D, Nath SK, Harley JB. Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13. Blood. 2003 Feb 1;101(3):992-7. Epub 2002 Sep 12.
Heinlen LD, McClain MT, Kim X, Quintero DR, James JA, Harley JB, Scofield RH. Anti-Ro and anti-nRNP response in unaffected family members of SLE patients. Lupus. 2003;12(4):335-7. No abstract available.
Nath SK, Quintero-Del-Rio AI, Kilpatrick J, Feo L, Ballesteros M, Harley JB. Linkage at 12q24 with Systemic Lupus Erythematosus (SLE) Is Established and Confirmed in Hispanic and European American Families. Am J Hum Genet. 2004 Jan;74(1):73-82. Epub 2003 Dec 04.
Nath SK, Kilpatrick J, Harley JB. Genetics of human systemic lupus erythematosus: the emerging picture. Curr Opin Immunol. 2004 Dec;16(6):794-800. Review.
Sawalha AH, Harley JB. Antinuclear autoantibodies in systemic lupus erythematosus. Curr Opin Rheumatol. 2004 Sep;16(5):534-40. Review.
Quintero-del-Rio AI, Kelly JA, Garriott CP, Hutchings DC, Frank SG, Aston CE, Harley JB. SLEN2 (2q34-35) and SLEN1 (10q22.3) replication in systemic lupus erythematosus stratified by nephritis. Am J Hum Genet. 2004 Aug;75(2):346-8. No abstract available.
Sawalha AH, Schmid WR, Binder SR, Bacino DK, Harley JB. Association between systemic lupus erythematosus and Helicobacter pylori seronegativity. J Rheumatol. 2004 Aug;31(8):1546-50.
Nath SK, Kelly JA, Harley JB, Scofield RH. Mapping the systematic lupus erythematosus susceptibility genes. Methods Mol Med. 2004;102:11-29. Review.
Nath SK, Namjou B, Garriott CP, Frank S, Joslin PA, Kilpatrick J, Kelly JA, Harley JB. Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3. Genes Immun. 2004 May;5(3):209-14.
Nath SK, Namjou B, Kilpatrick J, Garriott CP, Bruner GR, Scofield RH, Harley JB. A candidate region on 11p13 for systemic lupus erythematosus: a linkage identified in African-American families. J Investig Dermatol Symp Proc. 2004 Jan;9(1):64-7.
Record last reviewed: March 2005
Last Updated: March 21, 2005
Record first received: October 14, 2003
ClinicalTrials.gov Identifier: NCT00071175
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Autoimmune Diseases (Cleveland Clinic)
- Lupus (Cleveland Clinic)
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