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?Variola virus Virus classification Group: Group I (dsDNA) Family: Poxviridae Genus: Orthopoxvirus Species: Variola virus Smallpox (also known by the Latin names Variola or Variola vera) was a highly contagious viral disease unique to humans. It was caused by two virus variants called Variola major and Variola minor. V. major is the more deadly form, with a typical mortality of 20-40 percent of those infected. The other type, V. minor, only kills 1% of its victims. Ma ...
Wikipedia - [full article]
Smallpox Clinical Trials
- Dose On Safety, Tolerability, and Immunogenicity of ACAM2000 Smallpox Vaccine in Adults With Previous Smallpox Vaccination
ClinicalTrials.gov Identifier: NCT00053482 - Active, not recruiting
Smallpox
- Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination
ClinicalTrials.gov Identifier: NCT00053495 - Active, not recruiting
Smallpox
- Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults without Previous Smallpox Vaccination
ClinicalTrials.gov Identifier: NCT00053508 - Active, not recruiting
Smallpox
- Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers
ClinicalTrials.gov Identifier: NCT00103584 - Active, not recruiting
Smallpox
- Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax®
ClinicalTrials.gov Identifier: NCT00042094 - Active, not recruiting
Smallpox
- Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults
ClinicalTrials.gov Identifier: NCT00258947 - Active, not recruiting
Smallpox; Poxvirus Infection
- Safety and Immunogenicity of Smallpox Vaccine MVA-BN
ClinicalTrials.gov Identifier: NCT00082446 - Active, not recruiting
Smallpox
- VHA Clinicians and Bioterror Events: Interactive Web-Based Learning
ClinicalTrials.gov Identifier: NCT00123396 - Active, not recruiting
Smallpox; Anthrax
- A Double-Blind, Placebo-Controlled, Dose-Finding, Phase 2 Study to Assess the Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Modified Vaccinia Ankara Smallpox Vaccine
ClinicalTrials.gov Identifier: NCT00466245 - Active, not recruiting
Smallpox
- MVA Post-Event: Administration Timing and Boost Study
ClinicalTrials.gov Identifier: NCT00437021 - Recruiting
Smallpox; Variola Major (Smallpox)
- Immune Responses to Smallpox Vaccination
ClinicalTrials.gov Identifier: NCT00325975 - Recruiting
Smallpox Vaccine
- ACAM 3000 MVA at Harvard Medical School
ClinicalTrials.gov Identifier: NCT00133575 - Active, not recruiting
Variola major (smallpox)
- Dressing Preparation Comparison for Smallpox Vaccination Sites
ClinicalTrials.gov Identifier: NCT00063856 - Completed
Smallpox
- APSV in vaccinia naive adults
ClinicalTrials.gov Identifier: NCT00050518 - Completed
Smallpox
- Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults
ClinicalTrials.gov Identifier: NCT00079820 - Completed
Smallpox
- Human Immune Response to Smallpox Vaccine
ClinicalTrials.gov Identifier: NCT00068198 - Completed
Smallpox
- A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults
ClinicalTrials.gov Identifier: NCT00026611 - Completed
Smallpox
- Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive Subjects
ClinicalTrials.gov Identifier: NCT00189969 - Completed
Smallpox
- A Randomized, Double-Blind, Placebo-Controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy Subjects
ClinicalTrials.gov Identifier: NCT00316524 - Completed
Smallpox
- Dose-Finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine.
ClinicalTrials.gov Identifier: NCT00189956 - Completed
Smallpox
- Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients
ClinicalTrials.gov Identifier: NCT00316589 - Recruiting
HIV Infections
- A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic Dermatitis
ClinicalTrials.gov Identifier: NCT00316602 - Recruiting
Atopic Dermatitis
- Safety, Reactogenicity and Immunogenicity of MVA in HSCT Subjects
ClinicalTrials.gov Identifier: NCT00565929 - Not yet recruiting
Variola Major (Smallpox)
- Dryvax vaccine immunogenicity in previously vaccinated
ClinicalTrials.gov Identifier: NCT00050505 - Completed
Smallpox
- Assessment of dryvax in previously vaccinated adults
ClinicalTrials.gov Identifier: NCT00032708 - Completed
Smallpox
- Vaccinia virus vaccine (APSV) in vaccinia- naive subjects: PILOT
ClinicalTrials.gov Identifier: NCT00038987 - Completed
Smallpox
- Safety Study of MVA Smallpox Vaccine in HIV-Positive Subjects Who Are Vaccinia Naive
ClinicalTrials.gov Identifier: NCT00282581 - Terminated
HIV Infections; Smallpox
- A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated Volunteers
ClinicalTrials.gov Identifier: NCT00002261 - Completed
HIV Infections
- Safety Study of MVA Smallpox Vaccine in Subjects With a History of Atopic Dermatitis (AD)
ClinicalTrials.gov Identifier: NCT00389103 - Terminated
Smallpox; Atopic Dermatitis
- SIGA-246 to Treat Smallpox
ClinicalTrials.gov Identifier: NCT00303225 - Completed
Vaccinia
- Safety and Immunogenicity of CJ-50300
ClinicalTrials.gov Identifier: NCT00336635 - Completed
Smallpox
- Study on Safety, Tolerability and Immunogenicity of an MVA Vaccine Administered to Healthy Subjects
ClinicalTrials.gov Identifier: NCT00189943 - Completed
Smallpox
- Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected Patients
ClinicalTrials.gov Identifier: NCT00189904 - Completed
HIV Infections
- Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in Patients With Atopic Disorders
ClinicalTrials.gov Identifier: NCT00189917 - Completed
Dermatitis, Atopic; Hay Fever
- Phase I Trial of Smallpox Vaccine
ClinicalTrials.gov Identifier: NCT00046397 - Completed
Healthy
- A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of a Recombinant Vaccinia-HIV-1 IIIB Env/Gag/Pol Vaccine (TBC-3B)
ClinicalTrials.gov Identifier: NCT00000767 - Completed
HIV Infections
- Phase I/II Trial of Modified Vaccinia Virus Ankara (MVA) Vaccine against Smallpox
ClinicalTrials.gov Identifier: NCT00053742 - Completed
Healthy
Resources
- Adverse Events Associated with Smallpox Vaccination among Civilians (Centers for Disease Control and Prevention)
- Aide-Mémoire sur la Variole (World Health Organization)
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