RATIONALE: Tipifarnib may stop the growth of cancer cells by blocking the enzymes necessary for their growth.

PURPOSE: This randomized phase II trial is comparing how well 4 different tipifarnib regimens work in treating older patients with acute myeloid leukemia.

Condition	Treatment or Intervention	Phase
adult acute erythroid leukemia adult acute monoblastic and acute monocytic leukemia adult acute myeloid leukemia secondary acute myeloid leukemia	Drug: tipifarnib  Procedure: enzyme inhibitor therapy	Phase II

Further Study Details: 

OBJECTIVES:

• Determine the efficacy of 4 different regimens of tipifarnib in older patients with previously untreated acute myeloid leukemia.
• Provide increased access to this drug for these patients.
• Determine the frequency and severity of toxic effects of these regimens in these patients.
• Correlate, preliminarily, response to this drug with cytogenetics and assess whether karyotype represents a potential prognostic factor in patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are randomized to 1 of 4 treatment arms.

• Arm I: Patients receive oral tipifarnib twice daily on days 1-21.
• Arm II: Patients receive oral tipifarnib twice daily on days 1-7 and 15-21.
• Arm III: Patients receive a higher dose of oral tipifarnib as in arm I.
• Arm IV: Patients receive a higher dose of oral tipifarnib as in arm II. In all arms, courses repeat every 28 days in the absence of unacceptable toxicity or disease progression. Patients who acheive a complete remission (CR) receive up to 3 additional courses beyond CR. Patients in CR who develop recurrent disease after the completion of therapy are eligible to receive tipifarnib again.

Patients are followed every 3 months for 1 year, every 6 months for 1 year, and then annually for 3 years.

PROJECTED ACCRUAL: A total of 60-296 patients (15-74 per treatment arm) will be accrued for this study.

Ages Eligible for Study:  70 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Morphologically confirmed acute myeloid leukemia (AML) by bone marrow aspiration and biopsy
• No acute promyelocytic leukemia (FAB M3) or blastic transformation of chronic myelogenous leukemia
• Ineligible for or refused standard AML cytotoxic chemotherapy regimens
• Prior myelodysplastic syndromes (MDS) allowed
• Concurrent enrollment on SWOG-9007 (cytogenetics protocol) required (Southwest Oncology Group patients only)

PATIENT CHARACTERISTICS: Age

• 70 and over

Performance status

• Zubrod 0-2

Life expectancy

• Not specified

Hematopoietic

• WBC ≤ 30,000/mm^3 (hydroxyurea allowed)

Hepatic

• Bilirubin ≤ 1.5 times upper limit of normal (ULN)
• AST or ALT ≤ 2.5 times ULN

Renal

• Creatinine ≤ 1.5 times ULN

Other

• Fertile patients must use effective contraception
• Prior malignancy allowed

PRIOR CONCURRENT THERAPY: Biologic therapy

• Prior hematopoietic growth factors, thalidomide, or signal transduction inhibitors for MDS allowed
• Concurrent growth factors for MDS allowed

Chemotherapy

• No prior systemic chemotherapy for acute leukemia except hydroxyurea
• No prior AML induction type chemotherapy or high-dose chemotherapy with hematopoietic stem cell support for MDS
• Prior arsenic trioxide, azacitidine, or low-dose (< 100 mg/m^2/day) cytarabine for MDS allowed
• At least 6 months since chemotherapy for a prior malignancy

Endocrine therapy

• Concurrent hormonal therapy allowed

Radiotherapy

• At least 6 months since radiotherapy for a prior malignancy

Surgery

• Not specified

Other

• Recovered from all prior therapy
• Other prior low-intensity therapy for MDS allowed
• No concurrent therapy for MDS (other than growth factors)
• No antacids within 2 hours of tipifarnib administration
• No concurrent enzyme-inducing anticonvulsants, including phenytoin, fosphenytoin, phenobarbital, primidone, carbamazepine, and oxcarbazepine

Alabama
      MBCCOP - Gulf Coast, Mobile,  Alabama,  36607,  United States
      Northeast Alabama Regional Medical Center, Anniston,  Alabama,  36207,  United States
      University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham,  Alabama,  35294-3300,  United States
Arizona
      Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson,  Arizona,  85724,  United States
      CCOP - Mayo Clinic Scottsdale Oncology Program, Scottsdale,  Arizona,  85259-5404,  United States
      CCOP - Western Regional, Arizona, Phoenix,  Arizona,  85006-2726,  United States
      Veterans Affairs Medical Center - Phoenix (Carl T. Hayden), Phoenix,  Arizona,  85012,  United States
      Veterans Affairs Medical Center - Tucson, Tucson,  Arizona,  85723,  United States
Arkansas
      Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States
      Veterans Affairs Medical Center - Little Rock, Little Rock,  Arkansas,  72205,  United States
California
      CCOP - Bay Area Tumor Institute, Oakland,  California,  94609-3305,  United States
      CCOP - Santa Rosa Memorial Hospital, Santa Rosa,  California,  95403,  United States
      Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center, Orange,  California,  92868,  United States
      City of Hope Comprehensive Cancer Center, Duarte,  California,  91010-3000,  United States
      Community Hospital of the Monterey Peninsula, Monterey,  California,  93940,  United States
      Enloe Cancer Center at Enloe Medical Center, Chico,  California,  95926,  United States
      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1781,  United States
      Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States
      Memorial Medical Center Cancer Services, Modesto,  California,  95353,  United States
      Naval Medical Center - San Diego, San Diego,  California,  92134-3202,  United States
      Rebecca and John Moores UCSD Cancer Center, La Jolla,  California,  92093-0658,  United States
      Salinas Valley Memorial Hospital, Salinas,  California,  93901,  United States
      Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles,  California,  90048,  United States
      Stanford Cancer Center at Stanford University Medical Center, Stanford,  California,  94305-5216,  United States
      UCSF Comprehensive Cancer Center, San Francisco,  California,  94115,  United States
      University of California Davis Cancer Center, Sacramento,  California,  95817,  United States
      USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles,  California,  90033,  United States
      Veterans Affairs Medical Center - Palo Alto, Palo Alto,  California,  94304-1290,  United States
      Veterans Affairs Medical Center - San Diego, San Diego,  California,  92161,  United States
      Veterans Affairs Medical Center - San Francisco, San Francisco,  California,  94121,  United States
      Veterans Affairs Outpatient Clinic - Martinez, Martinez,  California,  94553,  United States
      Washington Township Hospital, Fremont,  California,  94538,  United States
Colorado
      Boulder Community Hospital, Boulder,  Colorado,  80301-9019,  United States
      Columbia Medical Center of Aurora North Campus, Aurora,  Colorado,  80011,  United States
      Hope Cancer Care Center at Longmont United Hospital, Longmont,  Colorado,  80501,  United States
      North Suburban Medical Center, Thornton,  Colorado,  80229,  United States
      Penrose Cancer Center at Penrose Hospital, Colorado Springs,  Colorado,  80933,  United States
      Porter Adventist Hospital, Denver,  Colorado,  80210,  United States
      Poudre Valley Hospital, Fort Collins,  Colorado,  80524,  United States
      Poudre Valley Radiation Oncology, Fort Collins,  Colorado,  80528,  United States
      Presbyterian - St. Luke's Medical Center, Denver,  Colorado,  80218,  United States
      Rose Medical Center, Denver,  Colorado,  80220,  United States
      Sky Ridge Medical Center, Lone Tree,  Colorado,  80124,  United States
      St. Joseph Hospital, Denver,  Colorado,  80218-1191,  United States
      St. Mary-Corwin Regional Medical Center, Pueblo,  Colorado,  81004,  United States
      University of Colorado Cancer Center at University of Colorado Health Sciences Center, Aurora,  Colorado,  80010,  United States
      Veterans Affairs Medical Center - Denver, Denver,  Colorado,  80220,  United States
Connecticut
      Bristol Hospital, Bristol,  Connecticut,  06011-5141,  United States
      Carl & Dorothy Bennett Cancer Center at Stamford Hospital, Stamford,  Connecticut,  06902,  United States
      Lawrence and Memorial Hospital, New London,  Connecticut,  06320,  United States
      Manchester Memorial Hospital, Manchester,  Connecticut,  06040-4188,  United States
      New Britain General Hospital, New Britain,  Connecticut,  06050-2000,  United States
      New London Cancer Center, New London,  Connecticut,  06320,  United States
      Northwestern Connecticut Oncology-Hematology Associates - Torrington, Torrington,  Connecticut,  06790-3012,  United States
      Praxair Cancer Center at Danbury Hospital, Danbury,  Connecticut,  06810,  United States
      Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center, Hartford,  Connecticut,  06105,  United States
      University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center, Farmington,  Connecticut,  06360-2875,  United States
      William W. Backus Hospital, Norwich,  Connecticut,  06360,  United States
      Yale Comprehensive Cancer Center, New Haven,  Connecticut,  06520-3289,  United States
Delaware
      Alfred I. duPont Hospital for Children, Wilmington,  Delaware,  19899,  United States
      CCOP - Christiana Care Health Services, Newark,  Delaware,  19713,  United States
      Nanticoke Memorial Hospital, Seaford,  Delaware,  19973,  United States
District of Columbia
      George Washington University Medical Center, Washington,  District of Columbia,  20037,  United States
      Lombardi Cancer Center at Georgetown University Medical Center, Washington,  District of Columbia,  20007,  United States
      MBCCOP - Howard University Cancer Center, Washington,  District of Columbia,  20060,  United States
      Walter Reed Army Medical Center, Washington,  District of Columbia,  20307-5001,  United States
Florida
      Baptist Cancer Institute - Jacksonville, Jacksonville,  Florida,  32207-8554,  United States
      Broward General Medical Center, Fort Lauderdale,  Florida,  33316,  United States
      CCOP - Mount Sinai Medical Center, Miami Beach,  Florida,  33140,  United States
      Florida Cancer Specialists, Sarasota,  Florida,  34231,  United States
      Florida Hospital Cancer Institute, Orlando,  Florida,  32804,  United States
      Florida Radiation Oncology Group, Orange Park,  Florida,  32073,  United States
      H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa,  Florida,  33612-9497,  United States
      Halifax Medical Center, Daytona Beach,  Florida,  32114,  United States
      Lakeland Regional Cancer Center at Lakeland Regional Medical Center, Lakeland,  Florida,  33804-1057,  United States
      Lee Cancer Care of Lee Memorial Health System, Fort Myers,  Florida,  33902,  United States
      Lynn Regional Cancer Center of Boca Raton Community Hospital, Boca Raton,  Florida,  33486,  United States
      Martin Memorial Cancer Center, Stuart,  Florida,  34994,  United States
      Mayo Clinic - Jacksonville, Jacksonville,  Florida,  32224,  United States
      Memorial Regional Cancer Center at Memorial Regional Hospital, Hollywood,  Florida,  33021,  United States
      North Broward Medical Center, Pompano Beach,  Florida,  33064-3596,  United States
      Palm Beach Cancer Institute - West Palm Beach, West Palm Beach,  Florida,  33401,  United States
      Patty Berg Cancer Center at Southwest Florida Regional Medical Center, Fort Myers,  Florida,  33901,  United States
      Shands Cancer Center at the University of Florida Health Science Center, Gainesville,  Florida,  32610-100277,  United States
      Space Coast Medical Associates, Titusville,  Florida,  32796,  United States
      Tampa General Hospital, Tampa,  Florida,  33606,  United States
      University of Florida Health Science Center - Jacksonville, Jacksonville,  Florida,  32209,  United States
      Veterans Affairs Medical Center - Tampa (Haley), Tampa,  Florida,  33612,  United States
      Watson Clinic, Lakeland,  Florida,  33804-5000,  United States
Georgia
      Cancer Care and Research Pavilion at St. Joseph's/Candler, Savannah,  Georgia,  31405-6015,  United States
      CCOP - Atlanta Regional, Atlanta,  Georgia,  30342-1701,  United States
      Georgia Cancer Center for Excellence at Grady Memorial Hospital, Atlanta,  Georgia,  30303,  United States
      MBCCOP-Medical College of Georgia Cancer Center, Augusta,  Georgia,  30912-4000,  United States
      Medical Center of Central Georgia, Macon,  Georgia,  31201,  United States
      Veterans Affairs Medical Center - Atlanta (Decatur), Decatur,  Georgia,  30033,  United States
      Winship Cancer Institute of Emory University, Atlanta,  Georgia,  30322,  United States
Hawaii
      MBCCOP - Hawaii, Honolulu,  Hawaii,  96813,  United States
Illinois
      Alexian Brothers Cancer Care Center, Elk Grove Village,  Illinois,  60007,  United States
      Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood,  Illinois,  60153-5500,  United States
      CCOP - Carle Cancer Center, Urbana,  Illinois,  61801,  United States
      CCOP - Central Illinois, Decatur,  Illinois,  62526,  United States
      CCOP - Evanston, Evanston,  Illinois,  60201,  United States
      CCOP - Illinois Oncology Research Association, Peoria,  Illinois,  61615-7828,  United States
      Center for Cancer Care at OSF Saint Anthony Medical Center, Rockford,  Illinois,  61108,  United States
      Decatur Memorial Hospital Cancer Care Institute, Decatur,  Illinois,  62526,  United States
      Deerpath Medical Associates, Lake Forest,  Illinois,  60045,  United States
      Edward H. Kaplan MD and Associates, Skokie,  Illinois,  60076,  United States
      Elmhurst Memorial Center for Health, Elmhurst,  Illinois,  60126,  United States
      Elmhurst Memorial Hospital, Elmhurst,  Illinois,  60126-2989,  United States
      Glenbrook Hospital, Glenview,  Illinois,  60025,  United States
      Hematology / Oncology Associates of Illinois, LLC, Melrose Park,  Illinois,  60160,  United States
      Hematology Oncology Associates - Skokie, Skokie,  Illinois,  60076,  United States
      Hematology-Oncology Associates of Illinois, Chicago,  Illinois,  60611-2998,  United States
      Hinsdale Hematology Oncology Associates, Hinsdale,  Illinois,  60521,  United States
      Holy Family Medical Center, Des Plaines,  Illinois,  60016,  United States
      Ingalls Memorial Hospital, Harvey,  Illinois,  60426,  United States
      John H. Stroger, Jr. Hospital of Cook County, Chicago,  Illinois,  60612-9985,  United States
      Joliet Oncology Hematology Associates, Limited - West, Joliet,  Illinois,  60435,  United States
      Leonard C. Ferguson Cancer Center, Freeport,  Illinois,  61032,  United States
      Louis A. Weiss Memorial Hospital, Chicago,  Illinois,  60640,  United States
      MBCCOP - University of Illinois at Chicago, Chicago,  Illinois,  60612,  United States
      Mercy Hospital and Medical Center, Chicago,  Illinois,  60616,  United States
      Midwest Cancer Research Group, Incorporated, Skokie,  Illinois,  60077,  United States
      Midwest Center for Hematology/Oncology, Joliet,  Illinois,  60432,  United States
      Morris Hospital, Morris,  Illinois,  60450,  United States
      North Shore Oncology Hematology Associates, Libertyville,  Illinois,  60048,  United States
      Regional Cancer Center at Memorial Medical Center, Springfield,  Illinois,  62781,  United States
      Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago,  Illinois,  60611,  United States
      Rush Cancer Institute at Rush University Medical Center, Chicago,  Illinois,  60612,  United States
      Saint Mary of Nazareth Hospital Center, Chicago,  Illinois,  60622,  United States
      Sherman Hospital, Elgin,  Illinois,  60120-2198,  United States
      St. Anthony's Memorial Hospital, Effingham,  Illinois,  62401,  United States
      Swedish Covenant Hospital, Chicago,  Illinois,  60625,  United States
      Swedish-American Regional Cancer Center, Rockford,  Illinois,  61104-2315,  United States
      Trinity Medical Center - West, Rock Island,  Illinois,  61201,  United States
      University of Chicago Cancer Research Center, Chicago,  Illinois,  60637-1470,  United States
      Veterans Affairs Medical Center - Chicago (Westside Hospital), Chicago,  Illinois,  60612,  United States
      Veterans Affairs Medical Center - Hines, Hines,  Illinois,  60141,  United States
      Veterans Affairs Medical Center - Lakeside Chicago, Chicago,  Illinois,  60611-4494,  United States
      Well Group Health Partners, Chicago Heights,  Illinois,  60411,  United States
      West Suburban Center for Cancer Care, River Forest,  Illinois,  60305,  United States
Indiana
      CCOP - Northern Indiana CR Consortium, South Bend,  Indiana,  46601,  United States
      Center for Cancer Therapy at LaPorte Hospital and Health Services, LaPorte,  Indiana,  46352,  United States
      Elkhart General Hospital, Elkhart,  Indiana,  46514-6514,  United States
      Fort Wayne Medical Oncology and Hematology, Incorporated, Fort Wayne,  Indiana,  46885-5099,  United States
      Indiana University Cancer Center, Indianapolis,  Indiana,  46202-5289,  United States
      Medical Consultants, P.C. at Ball Cancer Center, Muncie,  Indiana,  47303,  United States
      Methodist Cancer Center at Methodist Hospital, Indianapolis,  Indiana,  46206-1367,  United States
      Oncology and Hematology Associates, Indianapolis,  Indiana,  46227,  United States
      Oncology Institute of Greater Lafayette, Lafayette,  Indiana,  47904,  United States
      Oncology/Hemagology Associates of Southwest Indiana, Evansville,  Indiana,  47714,  United States
      Saint Anthony Memorial Health Centers, Michigan City,  Indiana,  46360-4358,  United States
      Saint Joseph Regional Medical Center, South Bend,  Indiana,  46617,  United States
      Veterans Affairs Medical Center - Indianapolis (Roudebush), Indianapolis,  Indiana,  46202,  United States
Iowa
      Alegent Health Community Memorial Hospital, Missouri Valley,  Iowa,  51555-1199,  United States
      Alegent Health Mercy Hospital, Council Bluffs,  Iowa,  51503,  United States
      Burgess Health Center, Onawa,  Iowa,  51040,  United States
      Cancer Center at Ottumwa Regional Health Center, Ottumwa,  Iowa,  52501,  United States
      CCOP - Cedar Rapids Oncology Project, Cedar Rapids,  Iowa,  52403-1206,  United States
      CCOP - Iowa Oncology Research Association, Des Moines,  Iowa,  50309-1016,  United States
      Des Moines General Hospital, Des Moines,  Iowa,  50309,  United States
      Holden Comprehensive Cancer Center at University of Iowa, Iowa City,  Iowa,  52242-1009,  United States
      John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines,  Iowa,  50316-2301,  United States
      John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines,  Iowa,  50309,  United States
      McFarland Clinic, P.C., Ames,  Iowa,  50010,  United States
      Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines,  Iowa,  50314,  United States
      Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City,  Iowa,  50401,  United States
      Saint Anthony Regional Hospital, Carroll,  Iowa,  51401,  United States
      St. Luke's Regional Medical Center, Sioux City,  Iowa,  51104-3761,  United States
      Veterans Affairs Medical Center - Des Moines, Des Moines,  Iowa,  50310-5774,  United States
Kansas
      Cancer Center of Kansas - Arkansas City, Arkansas City,  Kansas,  67005,  United States
      Cancer Center of Kansas - Chanute, Chanute,  Kansas,  66720,  United States
      Cancer Center of Kansas - Dodge City, Dodge City,  Kansas,  67801,  United States
      Cancer Center of Kansas - Kingman, Kingman,  Kansas,  67068,  United States
      Cancer Center of Kansas - Liberal, Liberal,  Kansas,  67901,  United States
      Cancer Center of Kansas - Newton, Newton,  Kansas,  67114,  United States
      Cancer Center of Kansas - Salina, Salina,  Kansas,  67401,  United States
      Cancer Center of Kansas - Wellington, Wellington,  Kansas,  67152,  United States
      Cancer Center of Kansas - Winfield, Winfield,  Kansas,  67156,  United States
      CCOP - Wichita, Wichita,  Kansas,  67214-3882,  United States
      Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City,  Kansas,  66160-7353,  United States
      Memorial Hospital, McPherson,  Kansas,  67460,  United States
      Pratt Cancer Center of Kansas, Pratt,  Kansas,  67124,  United States
      University of Kansas School of Medicine - Wichita, Wichita,  Kansas,  67214,  United States
      Veterans Affairs Medical Center - Wichita, Wichita,  Kansas,  67218,  United States
      Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita,  Kansas,  67214,  United States
      Wesley Medical Center, Wichita,  Kansas,  67214,  United States
      Wichita Clinic Cancer Medicine Associates, P.A., Wichita,  Kansas,  67208,  United States
Kentucky
      Baptist Hospital East - Louisville, Louisville,  Kentucky,  40207,  United States
      Caritas One Medical Center, Louisville,  Kentucky,  40215,  United States
      Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington,  Kentucky,  40536-0084,  United States
      Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County, Madisonville,  Kentucky,  42431,  United States
      Veterans Affairs Medical Center - Lexington, Lexington,  Kentucky,  40502-2236,  United States
Louisiana
      Cancer Center at Medical Center of Louisiana - New Orleans, New Orleans,  Louisiana,  70140-1015,  United States
      CCOP - Ochsner, New Orleans,  Louisiana,  70121,  United States
      Louisiana State University Health Sciences Center - Shreveport, Shreveport,  Louisiana,  71130-3932,  United States
      Mary Bird Perkins Cancer Center, Baton Rouge,  Louisiana,  70809,  United States
      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States
      Ochsner Clinic of Baton Rouge, Baton Rouge,  Louisiana,  70816-9990,  United States
      Terrebonne General Medical Center, Houma,  Louisiana,  70360,  United States
      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70112,  United States
      Veterans Affairs Medical Center - New Orleans, New Orleans,  Louisiana,  70112,  United States
      Veterans Affairs Medical Center - Shreveport, Shreveport,  Louisiana,  71101-4295,  United States
Maine
      Goodall Hospital, Sanford,  Maine,  04073,  United States
Maryland
      Cancer Center at Greater Baltimore Medical Center, Baltimore,  Maryland,  21204-6881,  United States
      DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis,  Maryland,  21401,  United States
      Frederick Memorial Hospital Regional Cancer Therapy Center, Frederick,  Maryland,  21701,  United States
      Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore,  Maryland,  21201,  United States
      Memorial Hospital at Easton, Easton,  Maryland,  21601,  United States
      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21231,  United States
      St. Agnes Cancer Center, Baltimore,  Maryland,  21229,  United States
      Suburban Hospital, Bethesda,  Maryland,  20817,  United States
Massachusetts
      Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield,  Massachusetts,  01107,  United States
      Beth Israel Deaconess Medical Center, Boston,  Massachusetts,  02215,  United States
      Cancer Center at Tufts - New England Medical Center, Boston,  Massachusetts,  02111,  United States
      Cancer Research Center at Boston Medical Center, Boston,  Massachusetts,  02118,  United States
      Caritas St. Elizabeth's Medical Center, Boston,  Massachusetts,  02135-2997,  United States
      Commonwealth Hematology-Oncology P.C. - Quincy, Quincy,  Massachusetts,  02169,  United States
      Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston,  Massachusetts,  02115,  United States
      Franklin Medical Center, Greenfield,  Massachusetts,  01301,  United States
      Lawrence Memorial Hospital of Medford, Medford,  Massachusetts,  02155,  United States
      MetroWest Medical Center - Framingham, Framingham,  Massachusetts,  01701,  United States
      Metrowest Medical Center, Leonard Morse Campus, Natick,  Massachusetts,  01760,  United States
      Morton Hospital & Medical Center, Taunton,  Massachusetts,  02780,  United States
      Mount Auburn Hospital, Cambridge,  Massachusetts,  02238,  United States
      Nashoba Valley Medical Center, Ayer,  Massachusetts,  01432,  United States
      Newton - Wellesley Hospital, Newton Lower Falls,  Massachusetts,  02462,  United States
      Saints Memorial Medical Center, Lowell,  Massachusetts,  01852,  United States
      UMASS Memorial Cancer Center - University Campus, Worcester,  Massachusetts,  01655,  United States
Michigan
      Barbara Ann Karmanos Cancer Institute, Detroit,  Michigan,  48201-1379,  United States
      Borgess Medical Center, Kalamazoo,  Michigan,  49001-1666,  United States
      Bronson Methodist Hospital, Kalamazoo,  Michigan,  49007-5364,  United States
      CCOP - Beaumont, Royal Oak,  Michigan,  48073-6769,  United States
      CCOP - Grand Rapids, Grand Rapids,  Michigan,  49503,  United States
      CCOP - Kalamazoo, Kalamazoo,  Michigan,  49007-3731,  United States
      CCOP - Michigan Cancer Research Consortium, Ann Arbor,  Michigan,  48106,  United States
      Genesys Hurley Cancer Institute, Flint,  Michigan,  48532,  United States
      Hickman Cancer Center at Bixby Medical Center, Adrian,  Michigan,  49221,  United States
      Hurley Medical Center, Flint,  Michigan,  48503,  United States
      Josephine Ford Cancer Center at Henry Ford Health System, Detroit,  Michigan,  48202,  United States
      Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph, Saint Joseph,  Michigan,  49085,  United States
      Providence Cancer Institute at Providence Hospital - Southfield, Southfield,  Michigan,  48075,  United States
      Seton Cancer Institute - Saginaw, Saginaw,  Michigan,  48601,  United States
      Sparrow Regional Cancer Center, Lansing,  Michigan,  48912-1811,  United States
      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0948,  United States
      Upper Michigan Cancer Center at Marquette General Hospital, Marquette,  Michigan,  49855,  United States
      Van Elslander Cancer Center at St. John Hospital and Medical Center, Detroit,  Michigan,  48236,  United States
      Veterans Affairs Medical Center - Detroit, Detroit,  Michigan,  48201-1932,  United States
      West Michigan Cancer Center, Kalamazoo,  Michigan,  49007-3731,  United States
Minnesota
      Cancer Care Center at Regions Hospital, Saint Paul,  Minnesota,  55101,  United States
      CCOP - Duluth, Duluth,  Minnesota,  55805,  United States
      CCOP - Metro-Minnesota, Saint Louis Park,  Minnesota,  55416,  United States
      Coborn Cancer Center, Saint Cloud,  Minnesota,  56303,  United States
      Fairview Ridges Hospital, Burnsville,  Minnesota,  55337,  United States
      Fairview Southdale Hospital, St. LouisPark,  Minnesota,  55416,  United States
      Hennepin County Medical Center - Minneapolis, Minneapolis,  Minnesota,  55415,  United States
      Hubert H. Humphrey Cancer Center at North Memorial Medical Center, Robbinsdale,  Minnesota,  55422-2900,  United States
      Hutchinson Area Health Care, Hutchinson,  Minnesota,  55350,  United States
      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905,  United States
      Meeker County Memorial Hospital, Lichfield,  Minnesota,  55355,  United States
      Mercy and Unity Cancer Center at Mercy and Unity Hospitals, Fridley,  Minnesota,  55432-2799,  United States
      Mercy Hospital, Coon Rapids,  Minnesota,  55433-2586,  United States
      Park Nicollet Clinic, St. Louis Park,  Minnesota,  55416,  United States
      Ridgeview Medical Center, Waconia,  Minnesota,  55387,  United States
      Saint Francis Cancer Center, Shakopee,  Minnesota,  55379,  United States
      St. John's Hospital, Maplewood,  Minnesota,  55109,  United States
      St. Joseph's Hospital, Saint Paul,  Minnesota,  55102,  United States
      St. Mary's - Duluth Clinic Cancer Center, Duluth,  Minnesota,  55805-1983,  United States
      United Hospital, Saint Paul,  Minnesota,  55102,  United States
      University of Minnesota Cancer Center, Minneapolis,  Minnesota,  55455,  United States
      Veterans Affairs Medical Center - Minneapolis, Minneapolis,  Minnesota,  55417-2399,  United States
      Virginia Piper Cancer Institute at Abbott-Northwestern Hospital, Minneapolis,  Minnesota,  55407,  United States
Mississippi
      Hattiesburg Clinic, P.A., Hattiesburg,  Mississippi,  39401,  United States
      University of Mississippi Medical Center, Jackson,  Mississippi,  39216-4505,  United States
      Veterans Affairs Medical Center - Jackson, Jackson,  Mississippi,  39216,  United States
Missouri
      CCOP - Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Kansas City, Kansas City,  Missouri,  64131,  United States
      CCOP - St. Louis-Cape Girardeau, Saint Louis,  Missouri,  63141,  United States
      Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia,  Missouri,  65203,  United States
      Missouri Baptist Cancer Center, Saint Louis,  Missouri,  63131,  United States
      Saint Louis University Cancer Center, Saint Louis,  Missouri,  63110,  United States
      Siteman Cancer Center at Barnes-Jewish Hospital, Saint Louis,  Missouri,  63110,  United States
      Veterans Affairs Medical Center - Columbia (Truman Memorial), Columbia,  Missouri,  65201,  United States
      Veterans Affairs Medical Center - Kansas City, Kansas City,  Missouri,  64128,  United States
Montana
      CCOP - Montana Cancer Consortium, Billings,  Montana,  59101,  United States
Nebraska
      Alegent Health - Immanuel Medical Center, Omaha,  Nebraska,  68122,  United States
      Bergan Mercy Medical Center, Omaha,  Nebraska,  68124,  United States
      Cancer Center at Creighton University Medical Center, Omaha,  Nebraska,  68131-2197,  United States
      Cancer Resource Center - Lincoln, Lincoln,  Nebraska,  68510-4844,  United States
      CCOP - Missouri Valley Cancer Consortium, Omaha,  Nebraska,  68106,  United States
      Fremont Area Medical Center, Fremont,  Nebraska,  68025-2387,  United States
      Mary Lanning Memorial Hospital, Hastings,  Nebraska,  68901,  United States
      Midlands Cancer Center at Midlands Community Hospital, Papillion,  Nebraska,  68128-4157,  United States
      UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha,  Nebraska,  68198-7680,  United States
      Veterans Affairs Medical Center - Omaha, Omaha,  Nebraska,  68105,  United States
Nevada
      CCOP - Southern Nevada Cancer Research Foundation, Las Vegas,  Nevada,  89106,  United States
      Sunrise Hospital and Medical Center, Las Vegas,  Nevada,  89109-2306,  United States
      Veterans Affairs Medical Center - Southern Nevada, Las Vegas,  Nevada,  89103,  United States
      Veterans Affairs Medical Center - Las Vegas, Las Vegas,  Nevada,  89106,  United States
      Washoe Cancer Services at Washoe Medical Center - Reno, Reno,  Nevada,  895020-0109,  United States
New Hampshire
      Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon,  New Hampshire,  03756-0002,  United States
New Jersey
      Booker Cancer Center at Riverview Medical Center, Red Bank,  New Jersey,  07701-9871,  United States
      Cancer Center at the Mountainside Hospital, Montclair,  New Jersey,  07042,  United States
      Cancer Institute of New Jersey at Hamilton, Hamilton,  New Jersey,  08690,  United States
      Cancer Institute of New Jersey at the Cooper University Hospital, Camden,  New Jersey,  08103,  United States
      Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick,  New Jersey,  08903,  United States
      CCOP - Northern New Jersey, Hackensack,  New Jersey,  07601,  United States
      Community Medical Center, Toms River,  New Jersey,  08755,  United States
      Fox Chase Cancer Center at St. Francis Medical Center, Trenton,  New Jersey,  08629,  United States
      Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees,  New Jersey,  08043,  United States
      Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital - Marlton, Mount Holly,  New Jersey,  08060,  United States
      Hunterdon Regional Cancer Center, Flemington,  New Jersey,  08822,  United States
      Jersey Shore Cancer Center at Jersey Shore University Medical Center, Neptune,  New Jersey,  07754,  United States
      John F. Kennedy Medical Center, Edison,  New Jersey,  08818,  United States
      Kimball Regional Cancer Center at Kimball Medical Center, Lakewood,  New Jersey,  08701,  United States
      Monmouth Medical Center, Long Branch,  New Jersey,  07710,  United States
      Morristown Memorial Hospital, Morristown,  New Jersey,  07962,  United States
      Ocean Medical Center at Meridian Health, Brick,  New Jersey,  08724,  United States
      Shore Memorial Hospital, Somers Point,  New Jersey,  08244-2387,  United States
      Somerset Medical Center, Somerville,  New Jersey,  08876,  United States
      South Jersey Regional Cancer Center, Millville,  New Jersey,  08332-8332,  United States
      Underwood Memorial Hospital, Woodbury,  New Jersey,  08096,  United States
      University Medical Center of Princeton, Princeton,  New Jersey,  08540,  United States
      Veterans Affairs Medical Center - East Orange, East Orange,  New Jersey,  07018,  United States
      Warren Hospital, Phillipsburg,  New Jersey,  08865,  United States
New Mexico
      Lovelace Medical Center at Lovelace Sandia Health System, Albuquerque,  New Mexico,  87108-4729,  United States
      MBCCOP - University of New Mexico HSC, Albuquerque,  New Mexico,  87131,  United States
      Santa Fe Cancer Center at St. Vincent Hospital, Santa Fe,  New Mexico,  87505,  United States
      Veterans Affairs Medical Center - Albuquerque, Albuquerque,  New Mexico,  87108-5138,  United States
New York
      Albert Einstein Cancer Center at Albert Einstein College of Medicine, Bronx,  New York,  10461,  United States
      CCOP - North Shore University Hospital, Manhasset,  New York,  11030,  United States
      CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., East Syracuse,  New York,  13057,  United States
      Herbert Irving Comprehensive Cancer Center at Columbia University, New York,  New York,  10032,  United States
      Interlakes Oncology/Hematology PC, Rochester,  New York,  14623,  United States
      James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester,  New York,  14642,  United States
      Lenox Hill Hospital, New York,  New York,  10021,  United States
      Long Island Cancer Center at Stony Brook University Hospital, Stony Brook,  New York,  11794-8174,  United States
      Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital, Cooperstown,  New York,  13326,  United States
      MBCCOP-Our Lady of Mercy Cancer Center, Bronx,  New York,  10466,  United States
      Memorial Sloan-Kettering Cancer Center, New York,  New York,  10021,  United States
      Montefiore Medical Center, Bronx,  New York,  10467-2490,  United States
      Mount Sinai Medical Center, New York,  New York,  10029,  United States
      New York Weill Cornell Cancer Center at Cornell University, New York,  New York,  10021,  United States
      North Shore Univ

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Source: ClinicalTrials.gov
Cache Date: April 9, 2005