The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.

Condition
Fibromyalgia Irritable Bowel Syndrome Chronic Fatigue Syndrome Depression

Further Study Details: 

Expected Total Enrollment:  560

FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.

Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.

Ages Eligible for Study:  12 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria

• Diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology
• Have at least one living family member who has also been diagnosed with fibromyalgia
• No other major rheumatological disease

Illinois
      University of Illinois at Peoria, Peoria,  Illinois,  60612,  United States; No longer recruiting
Ohio
      Case Western Reserve University, Cleveland,  Ohio,  44109,  United States; Recruiting
      University of Cincinnati, Cincinnati,  Ohio,  45221,  United States; Recruiting
Texas
      University of Texas Health Sciences Center, San Antonio,  Texas,  78229,  United States; No longer recruiting

Study chairs or principal investigators

Sudha Iyengar, PhD,  Study Chair,  Case Western Reserve University   

Study ID Numbers:  NIAMS-100
Record last reviewed:  October 2004
Last Updated:  October 26, 2004
Record first received:  October 14, 2003
ClinicalTrials.gov Identifier:  NCT00071162
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08