We wish to identify people with hypoglycemia (low blood sugar) and ultimately determine why the blood sugar levels are so low. To do so, we will contrast the responses of patients suspected to have hypoglycemia with those of healthy subjects during standardized tests. Those tests may include: 1) a controlled hypoglycemia produced by administration of insulin, a blood sugar-lowering hormone, and sugar, 2) a formula meal, and 3) a period of up to 72 hours without food.

Condition	Treatment or Intervention
Hypoglycemia	Procedure: Controlled hypoglycemia using insulin  Procedure: formula meal

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

• Patients with suspected hypoglycemia
• Healthy subjects (controls)
• Absence of known macrovascular disease or of known CNS disease by medical history, physical examination or ECG (exclusions for induced hypoglycemia)
• Ability to give informed consent

Missouri
      Washington University, St. Louis,  Missouri,  63110,  United States

Study ID Numbers:  NCRR-M01RR00036-0770; M01RR00036
Record last reviewed:  December 2003
Last Updated:  October 13, 2004
Record first received:  November 18, 2000
ClinicalTrials.gov Identifier:  NCT00006508
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08