The Vietnam Head Injusy Study (VHIS)-Phase III is a prospective, long-term follow-up study of head-injured Vietnam veterans. The purpose of this research study is to determine the long-term consequences, if any, of head injury.

Condition	Phase
Traumatic Brain Injury Penetrating head wounds Closed Head Trauma TBI	Phase III

Further Study Details: 

Expected Total Enrollment:  500

The VHIS - Phase III evaluation to be conducted approximately 30 years post-injury will be devoted to examining, cutting-edge cognitive neuroscience issues and will utilize state of the art technologies to address basic research questions in the following areas: (1) Functions of the human prefrontal cortex; (2) Cognitive neuroplasticity in the aging brain; (3) Memory; (4) Long-term behavioral and psychosocial outcome; and (5) Neurological studies, including an evaluation of post-traumatic epilepsy and repeat clinical measures from Phase - II. This testing will be complemented with structural neuroimaging, electroencephalogram (EEG) and molecular genetics. The goals of the VHIS – Phase III include providing clinicians and scientists new insights into the long term recovery of function following brain injury, the role of the prefrontal cortex in executive functions, better predictors of long term outcome (including cognitive, neurological, and genetic factors), and the effects of head injury incurred in youth on aging and the development of dementia.

Genders Eligible for Study:  Male

Accepts Healthy Volunteers

Criteria

We are seeking healthy CONTROL particpants.

Inclusion Criteria:

• Vietnam Veteran
• Served in active combat between 1966 - 1971
• Male

Exclusion Criteria:

• Any medical condition that would make participation detrimental to the control (i.e.: severe clinical depression, acute heart dysfunction, etc...)
• A history of severe head injury, stroke, loss of consciousness, or other significant neurological, psychiatric or medical condition that would render the subject unsuitable for the VHIS testing battery.

Please refer to this study by ClinicalTrials.gov identifier  NCT00132249

Sandra L Bonifant, BS      301-319-8471    BonifanS@ninds.nih.gov
Faith Bradford      301-319-8470    FABradford@bethesda.med.navy.mil

Maryland
      National Naval Medical Center, Bethesda,  Maryland,  20889,  United States; Recruiting

Study chairs or principal investigators

Jordan Grafman, PhD,  Principal Investigator,  Cognitive Neuroscience Section, NINDS, NIH   
Andres Salazar, MD,  Principal Investigator,  NINDS, NIH   

Study ID Numbers:  DAMD17-01-1-0675; NNMC IRB ID# B03-043
Last Updated:  August 18, 2005
Record first received:  August 17, 2005
ClinicalTrials.gov Identifier:  NCT00132249
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-08-23