Lung volume reduction surgery (LVRS) has been advanced as a therapy to significantly improve quality of life in patients with COPD, but to date no controlled studies have evaluated the impact of LVRS. Evaluate cost-effectiveness of LVRS compared to current therapy for COPD. This is a case control study in which veterans undergoing LVRS at VA Puget Sound Health Care System (VAPSHCS) are compared to patients with a similar severity of disease at Boise VAMC who are not undergoing LVRS. Changes in health related quality of life are being evaluated using three instruments: the SF-36, the St. George?s Respiratory Questionnaire, and the Quality of Well-Being Scale, the latter to calculate utility associated with different health states. Costs will be determined using utilization data on outpatient visits, medications, oxygen use, inpatient days, radiology tests, laboratory tests, and emergency room visits are being collected for the twelve months before and after surgery. Costs will be calculated according to VA and community standards.

Condition	Treatment or Intervention	Phase
Chronic Obstructive Pulmonary Disease Emphysema	Procedure: Case control study comparing pts undergoing LVRS with those not undergoing LVRS.	Phase II

Further Study Details: 

Expected Total Enrollment:  92

Ages Eligible for Study:  18 Years   -   75 Years,  Genders Eligible for Study:  Male

Criteria

Severe COPD as defined by FEV1 of 20-30% predicted; marked hyperinflation with a residual volume of >165% predicted; 6-min walk greater than 600 ft; abstinence from cigarette smoking for 3-mths; absence of co-morbid illnesses that would significantly increase surgical risk, such as severe coronary artery disease

Vermont
      VA Medical & Regional Office Center, White River Junction,  Vermont,  05009-0001,  United States
Washington
      Seattle Medical Center, Seattle,  Washington,  98108,  United States

Study ID Numbers:  IIR 96-024
Record last reviewed:  October 1999
Last Updated:  October 13, 2004
Record first received:  March 14, 2001
ClinicalTrials.gov Identifier:  NCT00013156
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08