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The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle - Article


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Clinical Trial: The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle

This study is currently recruiting patients.
Verified by Imperial College London September 2005

Sponsors and Collaborators: Imperial College London
Magstim Company, Whitland, Wales
Information provided by: Imperial College London
ClinicalTrials.gov Identifier: NCT00159367

Purpose

We intend to use repetitive magnetic stimulation to the quadriceps muscle to try to improve strength and improve the metabolic function of the muscle.
Condition Intervention
Chronic Obstructive Pulmonary Disease
 Device: Repetitive magnetic stimulation to the quadriceps

MedlinePlus related topics:  COPD (Chronic Obstructive Pulmonary Disease)

Study Type: Interventional
Study Design: Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study

Official Title: The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle in Patients with Chronic Obstructive Pulmonary Disease

Further Study Details: 
Primary Outcomes: Quadriceps Twitch force
Secondary Outcomes: Quadriceps maximal voluntary contraction, Oxidative enzyme profile, fibre type distribution and capillarity of the muscle, quality of life questionnaires
Expected Total Enrollment:  20

Study start: January 2005;  Expected completion: December 2006
Last follow-up: October 2006;  Data entry closure: December 2006

Quadriceps strength is reduced in COPD. Increasing quadriceps strength is one of the goals of pulmonary rehabilitation yet some patients with severe COPD are unable to exercise with sufficient intensity, due to breathlessness, to achieve a true training benefit.

Transcutaneous electrical stimulation of the femoral nerve has been shown to improve quadriceps muscle strength, muscle mass, and performance in patients with severe COPD. Magnetic stimulation may be preferred because it offers the opportunity to train the whole muscle and because it is painless. In this pilot study we are investigating whether repetitive magnetic stimulation camn increase the strength of the quadriceps muscle and whether it confers any change in structure or metabolism of the muscle itself.

Eligibility

Ages Eligible for Study:  40 Years   -   85 Years,  Genders Eligible for Study:  Both
Criteria

Inclusion Criteria:

Chronic Obstructive Pulmonary Disease

Exclusion Criteria:

Aspirin therapy Cardiac Pacemaker

-

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00159367

Michael I Polkey, PhD      +44 207 351 8029    m.polkey@rbht.nhs.uk

United Kingdom
      Royal Brompton Hospital, London,  Sw3 6NP,  United Kingdom; Recruiting
Michael I Polkey, PhD  +44 207 351 8029    m.polkey@rbht.nhs.uk 
Elisabeth B Swallow, MD,  Sub-Investigator

Study chairs or principal investigators

Michael I Polkey, PhD,  Principal Investigator,  Imperial College   

More Information

Study ID Numbers:  RR1; EU QLRT-2001-2285
Last Updated:  September 11, 2005
Record first received:  September 9, 2005
ClinicalTrials.gov Identifier:  NCT00159367
Health Authority: United Kingdom: Research Ethics Committee
ClinicalTrials.gov processed this record on 2005-09-13

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