Clinical Trial: Behavior Enhances Drug Reduction of Incontinence (BE-DRI)

This study is currently recruiting patients.

Sponsors and Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute of Child Health and Human Development (NICHD)
Information provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)


The primary aim of this study is to test if the addition of behavioral treatment to drug therapy for the treatment of urge incontinence will increase the number of patients who can discontinue drug therapy and sustain a significant reduction of incontinence.

Condition Treatment or Intervention Phase
Urinary Incontinence
 Drug: Tolterodine
 Behavior: Combination Drug (tolterodine) and Behavior Treatment
Phase II
Phase III

MedlinePlus related topics:  Urinary Incontinence

Study Type: Interventional
Study Design: Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study

Official Title: Behavior Enhances Drug Reduction of Incontinence

Further Study Details: 

Expected Total Enrollment:  300

Study start: August 2004;  Expected completion: June 2006


Ages Eligible for Study:  21 Years and above,  Genders Eligible for Study:  Female

Accepts Healthy Volunteers



  • Female
  • Urge predominant incontinence
  • Incontinent > 3 mos
  • Available for 8 mos of followup


  • Pregnancy or < 6 mos post-partum
  • Hypersensitivity to drug (tolterodine)
  • Systemic disease that affects bladder function (e.g., Parkinson's disease, MS, spinal cord injury)
  • History of extensive behavior treatment

Location and Contact Information

Sharon L Tennstedt, Ph.D.      (617) 923-7747  Ext. 362
Kimberly Dandreo, M.S.      (617) 923-7747  Ext. 219

      University of Alabama, Birmingham,  Alabama,  35233,  United States; Recruiting
Holly Richter, MD  205-934-7874 
Alice A Howell, RN  205-975-8592 
Holly Richter, MD,  Principal Investigator
L. Keith Lloyd, MD,  Sub-Investigator
Rowell Ashford, MD,  Sub-Investigator
Kathryn Burgio, PhD,  Sub-Investigator
Seine Chiang, MD,  Sub-Investigator
Patricia S. Goode, MD,  Sub-Investigator
Lee Hammontree, MD,  Sub-Investigator
R. Edward Varner, MD,  Sub-Investigator

      University of California, San Diego,  California,  92103,  United States; Recruiting
Michael Albo, MD  858-657-8435 
D. Lynn Kalinoski, PhD  619-543-2169 
Michael Albo, MD,  Principal Investigator
Charles Nager, MD,  Sub-Investigator
Christine Dorr, MD,  Sub-Investigator
Karl M. Luber, MD,  Sub-Investigator
Emily Lukacz, MD,  Sub-Investigator
Amanda Simsiman, MD,  Sub-Investigator

      Loyola University Medical Center, Maywood,  Illinois,  60153,  United States; Recruiting
Linda Brubaker, MD  708-216-2170 
Kathy Jesse, RN  708-216-8944 
Linda Brubaker, M.D,  Principal Investigator
MaryPat Fitzgerald, MD,  Sub-Investigator
Kimberly Kenton, MD,  Sub-Investigator

      University of Maryland, Baltimore,  Maryland,  21201,  United States; Recruiting
Toby Chai, MD  410-328-5544 
Judith Murray, CCRC  410-328-5784 
Toby Chai, MD,  Principal Investigator
Harry Johnson, MD,  Sub-Investigator

      Oakwood Hospital and Medical Center, Royal Oak,  Michigan,  48123,  United States; Recruiting
Veronica Mallett, MD  313-436-2201 
Kathryn Koches, RN  313-436-2242 
Ananias C Diokno, MD,  Principal Investigator
Veronica Mallett, MD,  Sub-Investigator
Salil Khandwala, MD,  Sub-Investigator

      University of Pittsburgh, Pittsburgh,  Pennsylvania,  15213,  United States; Recruiting
Halina Zyczynski, MD  412-641-1440 
Judith Gruss, RN  412-641-5388 
Halina Zyczynski, MD,  Principal Investigator
Wendy Leng, MD,  Sub-Investigator
Pamela A Moalli, MD,  Sub-Investigator
Elizabeth Sagan, MD,  Sub-Investigator

      University of Texas Southwestern, Dallas,  Texas,  75390,  United States; Recruiting
Philippe Zimmern, MD  214-648-9397 
Norma Pope, RN, WHNP  214-645-8791 
Philippe Zimmern, MD,  Principal Investigator
Gary E. Lemack, MD,  Sub-Investigator
Muriel Boreham, MD,  Sub-Investigator
Mikio Nihira, MD, MPH,  Sub-Investigator
Joseph Schaffer, MD,  Sub-Investigator
Clifford Wai, MD,  Sub-Investigator

      University of Texas Health Sciences Center, San Antonio,  Texas,  78229,  United States; Recruiting
Stephen Kraus, MD  210-567-5650 
Sylvia Escobedo Sluder, CCRP  210-567-0550 
Stephen Kraus, MD,  Principal Investigator
Ash Dabbous, MD,  Sub-Investigator
Alayne Markland, DO,  Sub-Investigator

      University of Utah, Salt Lake City,  Utah,  84132,  United States; Recruiting
Peggy Norton, MD  801-581-3565 
Shelly O'Meara, RN  801-581-6874 
Peggy Norton, MD,  Principal Investigator
Lindsey Kerr, MD,  Sub-Investigator
Jan Baker, APRN,  Sub-Investigator
David Lesser, MD,  Sub-Investigator

Study chairs or principal investigators

William D Steers, M.D.,  Study Chair,  University of Virginia   

More Information

Study ID Numbers:  BE-DRI
Record last reviewed:  February 2005
Last Updated:  February 7, 2005
Record first received:  August 27, 2004 Identifier:  NCT00090584
Health Authority: United States: Federal Government processed this record on 2005-04-08

Cache Date: April 9, 2005