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  • First U.S. Tuberculosis Vaccine Trial in 60 Years Begins
    A new vaccine, made with several proteins from the bacterium that causes tuberculosis (TB), will soon enter the first phase of human safety testing. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has supported research on the candidate vaccine from its earliest stages. The trial will be conducted in the United States by Seattle biotechnology company Corixa and GlaxoSmithKline Biologicals, a vaccine manufacturer headquartered in...
    National Institutes of Health
  • Selenium and Vitamin E Cancer Prevention Trial : Q & A
    Key Points SELECT stands for the Selenium and Vitamin E Cancer Prevention Trial, a clinical trial to see if one or both of these dietary supplements prevent prostate cancer (see Question 1). Selenium and vitamin E are antioxidants. Two earlier studies suggested that these two supplements might prevent prostate cancer (see Questions 3, 4, and 5). In order to participate in SELECT, men had to meet certain eligibility requirements (see Questions 6, 7, and 8). Men who participate in this study were...

  • Small Trial Shows Daclizumab Add-On Therapy Improves Multiple Sclerosis Outcome
    A small clinical trial of patients with multiple sclerosis (MS) who did not respond to interferon alone found that adding the human antibody daclizumab improved patient outcome. Patients who received the combined therapy had a 78 percent reduction in new brain lesions and a 70 percent reduction in total lesions, along with other significant clinical improvements. The trial was led by investigators at the National Institute of Neurological Disorders and Stroke (NINDS), a component of the...
    National Institutes of Health
  • National Lung Screening Trial Reaches Goal of 50,000 Participants
    The National Cancer Institute (NCI), part of the National Institutes of Health, in partnership with the American Cancer Society, has enrolled its goal of 50,000 current or former smokers in the National Lung Screening Trial (NLST). The study, launched in September 2002, was designed to determine if screening with either spiral computed tomography (CT) or chest X-ray before the appearance of symptoms can reduce deaths from lung cancer. Although the trial has reached its 50,000 participant goal,...
    National Institutes of Health
  • Diabetes Control and Complications Trial (DCCT)
    The DCCT is a clinical study conducted from 1983 to 1993 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The study showed that keeping blood glucose levels as close to normal as possible slows the onset and progression of eye, kidney, and nerve diseases caused by diabetes. In fact, it demonstrated that any sustained lowering of blood glucose helps, even if the person has a history of poor control. The largest, most comprehensive diabetes study ever conducted,...
    National Institute of Diabetes and Digestive and Kidney Diseases

Clinical Trials

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November 25, 2009



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