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All Topic Areas 1 - 10 of 62  more >> Genes and Gene Therapy Human Genome Project BRCA PSEN1 CF Gene Mutation Pantothenate kinase-associated neurodegeneration NBIA1 Neurodegeneration with Brain Iron Accumulation Type 1 PKAN Apolipo-protein E (apoe) Gene Articles 1 - 5 of 21  more >> Schizophrenia Gene Variant Linked to Risk Traits Researchers at the NIH's National Institute of Mental Health (NIMH) have identified a relationship between a small section of one gene, the brain chemical messenger glutamate, and a collection of traits known to be associated with schizophrenia. The finding confirms the gene responsible for management of glutamate is a promising candidate in determining risk for schizophrenia. The study, conducted by Michael Egan, M.D., Daniel Weinberger, M.D., and colleagues, will be in the August 24th issue... National Institutes of Health Gene Therapy for Cancer: Questions and Answers Key Points Gene therapy is an experimental treatment that involves introducing genetic material into a person’s cells to fight disease (see Question 2). Researchers are studying gene therapy for cancer through a number of different approaches (see Question 3). A gene can be delivered to a cell using a carrier known as a “vector.” The most common types of vectors used in gene therapy are viruses (see Question 4). The viruses used in gene therapy are altered to make them safe;... Mutant Gene Linked to Obsessive Compulsive Disorder Analysis of DNA samples from patients with obsessive compulsive disorder (OCD) and related illnesses suggests that these neuropsychiatric disorders affecting mood and behavior are associated with an uncommon mutant, malfunctioning gene that leads to faulty transporter function and regulation. Norio Ozaki, M.D., Ph.D., and colleagues in the collaborative study explain their findings in the October 23 Molecular Psychiatry. Researchers funded by the National Institutes of Health have found a... National Institutes of Health Study Reveals Patterns of Gene Activity in the Mouse Nervous System The first published data from a government-funded project provide remarkable new insights into where specific genes are active in the mouse nervous system during development and adulthood. Information from this project will advance researchers' understanding of how particular genes function in the brain and spinal cord, leading to insights about how the nervous system works. It also may lead to new ways of preventing or treating disorders such as Parkinson's disease, Alzheimer's, psychiatric... National Institutes of Health Gene Hunting Many years of research have demonstrated that vulnerability to mental illnesses—such as schizophrenia, bipolar disorder, early-onset depression, anxiety disorders, autism, and attention deficit hyperactivity disorder—has a genetic component. It is now clear that these disorders are not due to a single defective gene, but to the joint effects of many genes acting together with nongenetic factors.1,2,3 Despite the daunting complexity, progress is being made. Researchers are hunting genes... National Institute of Mental Health News 1 - 5 of 1876  more >> Protein Stops P53 In Its Tracks In Cancer Cells ScienceDaily - Wed, 21 Feb 2007 04:00 EST Turning A Cellular Sentinel Into A Cancer Killer MedicalNewsToday - Mon, 29 Jan 2007 11:00 EST HMGA1 Stops P53 In Its Tracks In Cancer Cells MedicalNewsToday - Wed, 14 Feb 2007 01:00 EST Tumors Shrink When Gene Reactivated MedicalNewsToday - Tue, 30 Jan 2007 01:00 EST Genes And Genius: Researchers Confirm Association Between Gene And Intelligence ScienceDaily - Tue, 27 Feb 2007 04:00 EST Clinical Trials 1 - 5 of 330  more >> Chemotherapy With or Without Gene Therapy in Treating Patients With Unresectable Recurrent Head and Neck Cancer ClinicalTrials.gov Identifier: NCT00040716 - Recruiting Head and Neck Cancer Comparison of Gene Therapy With Chemotherapy in Treating Patients With Head and Neck Cancer ClinicalTrials.gov Identifier: NCT00040703 - Recruiting Head and Neck Cancer Gene Therapy and Surgery Followed by Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Cancer of the Mouth or Throat ClinicalTrials.gov Identifier: NCT00017173 - Active, not recruiting Hypopharyngeal Cancer; Laryngeal Cancer; lip and oral cavity cancer; Oropharyngeal Cancer Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome ClinicalTrials.gov Identifier: NCT00406445 - Recruiting Li-Fraumeni Syndrome; Cardiovascular Capacity Gene Therapy in Treating Patients With Recurrent Head and Neck Cancer ClinicalTrials.gov Identifier: NCT00003257 - Active, not recruiting recurrent squamous cell carcinoma of the hypopharynx; recurrent squamous cell carcinoma of the larynx; ...

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