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  • Bone Marrow and Peripheral Blood Stem Cell Transplantation: Q & A
    Key Points Hematopoietic or blood-forming stem cells are immature cells that can mature into blood cells. These stem cells are found in the bone marrow, bloodstream, or umbilical cord blood (see Question 1). Bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) are procedures that restore stem cells that were destroyed by high doses of chemotherapy and/or radiation therapy (see Questions 2 and 3). In general, patients are less likely to develop a complication...

  • NIGMS Center Grants to Explore Stem Cell Biology
    Bethesda, Maryland — Flexible in their fate, human embryonic stem cells can become any one of the more than 200 cell types that make up the human body. Because of this flexibility, stem cells hold promise for solving mysteries about the fundamental biology of all cells. "America's scientists need powerful tools to find better ways to diagnose and treat health problems," said Health and Human Services Secretary Tommy G. Thompson. "Understanding the biology of stem cells can help fill in the...
    National Institutes of Health
  • Sickle Cell Anemia
    Sickle cell anemia affects the red blood cells. Normal red blood cells are smooth and round like doughnuts. They move easily through blood vessels to carry oxygen to all parts of the body. In sickle cell anemia, the red blood cells become hard, sticky, and shaped like sickles or crescents. When these hard and pointed red cells go through the small blood vessels, they tend to get stuck and block the flow of blood. This can cause pain, damage, and a low blood count or anemia. The sickle-shaped...
    National Heart, Lung, and Blood Institute Information Center, NHLBI, NIH, HHS
  • High Blood Pressure in the Lungs a Major Risk for Death in Adults with Sickle Cell Disease
    A new study reveals that nearly one third of adults with sickle cell disease develop high blood pressure in their lungs and that the condition, known as pulmonary hypertension, causes a much higher death rate in patients with the complication than those without it. The findings, according to researchers from the Warren Grant Magnuson Clinical Center at the National Institutes of Health (NIH), demonstrate an urgent need to diagnose this complication in adults with sickle cell disease as it is a...
    National Institutes of Health
  • Hydroxyurea Therapy Improves Survival in Most Severely Affected Sickle Cell Patients
    Sickle cell anemia patients who took the drug hydroxyurea over a 9-year period experienced a 40 percent reduction in deaths, according to the first study to evaluate whether the treatment prolongs life, announced the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health. The study of 299 adult sickle cell patients with moderate to severe forms of the disease, found that improved survival was related to the benefits associated with hydroxyurea treatment — an...
    National Institutes of Health

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November 25, 2009



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