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Central pontine myelinolysis as related to Spironolactone


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Aldactone 

Central pontine myelinolysis is a neurologic disease caused by severe damage of the myelin sheath of nerve cells in the brainstem, more precisely ...

Spironolactone (marketed as Aldactone or Spiritone) is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. ...


Central pontine myelinolysis as related to Spironolactone


  • management - General Practice Notebook
    Patients with a plasma sodium concentration greater than 125 mmol/l rarely need ... they can develop central pontine myelinolysis (osmotic demyelination) following ...

  • ISPUB - Management of hyponatraemia in cirrhotic ascites
    Hyponatremia is a commonly encountered problem in patients with ascites and its incidence ... by more than 12meq/l per day is necessary to avoid central pontine myelinolysis. ...

  • Hyponatraemia in clinical practice
    Chronic hyponatraemia should be treated with caution because of the risk of central pontine myelinolysis. Keywords: hyponatraemia, sodium, water balance, AVP, SIADH ...

  • Diuretics :: adverse effects
    ... genotype with potassium response to spironolactone in patients with heart failure. Drug ... findings typical of central pontine myelinolysis, which developed after the patients ...

  • [전문]
    중심성교뇌수초용해(central pontine myelinolysis; CPM)는 1959년 Adams 등이 알코올중독과 ... which is also called central pontine myelinolysis (CPM). However, demyelinating lesions ...

  • Microsoft PowerPoint - SpR electrolytes deanery.ppt [Read-Only]
    Central pontine myelinolysis. • Avoid rapid correction of chronic ... 5) inappropriately high doses of spironolactone. 6) inappropriate use of other drugs that ...

  • Microsoft PowerPoint - 030306 Renal Pathophysiology
    Central pontine myelinolysis. Loop. • Interfere with Na+/K+/2Cl- at thick ascending. portion ... Spironolactone. • Work only if aldosterone levels are high. • Liver ...

  • Hyponatraemia (Case Presentation)
    A case of severe hyponatraemia with a discussion of sodium and water balance ... increase in serum sodium per day only – risk of central pontine myelinolysis ...

  • CME LLC
    About | Resources | My Account | Help | Search | Contact. PSYCHIATRY ... central pontine myelinolysis, which can lead to irreversible degeneration of nerve fibers. ...

  • Profound hyponatremia in cirrhosis: a case report
    ... restriction and continued treatments with spironolactone and loop diuretics. ... iatrogenic brain injury and central pontine myelinolysis 1314. In patients with ...

  • http://circ.ahajournals.org/cgi/content/full/102/suppl_1/I-217?
    hyponatremia can cause pontine myelinolysis , a lethal disorder ... Central pontine myelinolysis. and pontine lesions after rapid correction of hyponatremia: ...

  • Nutrition and Metabolism Disorders
    A definition of central pontine myelinolysis, including the causes, risks, ... Central Pontine Myelinolysis: An introduction, clinical features, differencials, ...

  • Part 8: Advanced Challenges in Resuscitation : Section 1 ...
    Potassium-sparing diuretics such as spironolactone, triamterene, and amiloride are well ... Central pontine myelinolysis and pontine lesions after rapid ...

  • Cases Journal | Full text | Profound hyponatremia in ...
    © 2010 Lindsay; licensee BioMed Central Ltd. This is an Open Access article distributed ... hours to prevent iatrogenic brain injury and central pontine myelinolysis [13,14] ...

  • Potassium Sparing Diuretic
    Central pontine myelinolysis. Cerebral salt-wasting syndrome ... as amiloride (Midamor, Moduretic), spironolactone (Aldactone, Aldactazide), triamterene ...

  • Profound hyponatremia in cirrhosis: a case report
    Copyright ©2010 Lindsay; licensee BioMed Central Ltd. Profound hyponatremia in cirrhosis: ... hours to prevent iatrogenic brain injury and central pontine myelinolysis [13,14] ...

  • Microsoft PowerPoint - 20051125_lytes_np
    risks central pontine myelinolysis. Case. • 30 year old female presents ... ACE-I, ARBs, spironolactone, NSAIDs. • Pseudohyperkalemia. – check CBC ...

  • Pathophysiology of ascites and dilutional hyponatremia ...
    ministration of diuretics (spironolactone 100-400 mg/day. in combination with the loop ... lead to central pontine myelinolysis. 38. The duration of. the ...

  • PERSPECTIVES ON DISEASE
    This site complies with the HONcode standard for trustworthy health information: ... Senile macular degeneration: Central blindness due to old age. Senile cataract: ...

  • Spinocerebellar ataxia: Definition from Answers.com
    spinocerebellar ataxia abbr. : SCA; any of a heterogeneous group (SCA1 to SCA10) of neurological disorders caused by variable degrees of degeneration

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May 19, 2013



Page Updated: January 17, 2010
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