Clozapine (trade names Clozaril®; Leponex®), approved by the FDA in 1989, was the first of the atypical antipsychotics. Clozapine is the only FDA approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia.

Barbiturate intoxication and overdose as related to Clozapine