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Achalasia as related to Metformin


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Achalasia or acalasia is a failure of a ring of muscle (as a sphincter) to relax (completely). It refers most commonly to esophageal achalasia, which is a neuromuscular disorder of the esophagus characterized by the reduced ability to move food down the esophagus (peristalsis). In addition, the inability of the cardia ( also called lower esophageal sphincter)- to relax in response to swallowing (there is increased LES pressure- spasms).

Metformin (Glucophage®) is an anti-diabetic drug from the biguanide class (its other members are the withdrawn agents phenformin and buformin).


Achalasia as related to Metformin


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December 1, 2009


Page Updated: January 17, 2009
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