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Spironolactone as related to 21-hydroxylase deficiency


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Aldactone 

Adrenogenital Syndrome; Congenital Adrenal Hyperplasia; Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficie... 

Spironolactone (marketed as Aldactone or Spiritone) is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. ...

21-hydroxylase deficiency is a disorder of steroid metabolism (the buildup or breakdown of steroids). Steroids are types of lipids (fats) that include cholesterol, vitamin D, and many hormones. The 21-hydroxylase deficiency results in the inability of the body to produce cortisol and aldosterone (steroid hormones that affect metabolism and salt balance, respectively) from cholesterol. This condition is also known as congenital adrenal hyperplasia. When the precursors of these hormones build up ...


Spironolactone as related to 21-hydroxylase deficiency


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November 23, 2009


Page Updated: January 17, 2009
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