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Diffuse Globoid Body Sclerosis; Galactosylceramidase Deficiency Disease; Galactosylceramide lipidosis; galactosylcerebro... 

 

Krabbe disease is a degenerative disorder that affects the nervous system. It is caused by the shortage (deficiency) of an enzyme called galactosylceramidase (GALC). This enzyme deficiency results in defective myelin, the covering that insulates many nerves. Krabbe disease is considered part of a group of disorders known as leukodystrophies, which result from the imperfect growth and development of myelin. Krabbe disease usually begins before the age of 1 year (early-onset form). Initial sign...


Krabbe Disease as related to Globoid Cell Leukodystrophy