Adrenoleukodystrophy (ALD) is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, an insulating membrane that surrounds nerve cells in the brain. People with ALD accumulate high levels of saturated, very long chain fatty acids (VLCFA) in the brain and adrenal cortex because they do not produce the enzyme that breaks down these fatty acids in the normal manner. ALD has two subtypes. The most common is the X-linked form (X-ALD), which involves an...

Acetyl-L-carnitine (ALCAR) is an acetylated form of L-carnitine, which is far superior to normal L-carnitine in terms of bioavailability. ALCAR is absorbed by the gastrointestinal tract, enters cells and crosses the blood-brain barrier more readily than unacetylated carnitine.

Adrenoleukodystrophy as related to Acetyl-L-Carnitine