Acid Reflux; Gastroesophageal Reflux; Gastroesophageal Reflux (GERD); Gastroesophageal Reflux Disease; Gastroesophageal ... 


Gastroesophageal reflux disease, or GERD, occurs when the lower esophageal sphincter (LES) does not close properly and stomach contents leak back, or reflux, into the esophagus. The LES is a ring of muscle at the bottom of the esophagus that acts like a valve between the esophagus and stomach. The esophagus carries food from the mouth to the stomach.

Chemicals that suppress stomach acid secretion by inhibiting a specific enzyme system on the surface of the stomach's parietal cells. This enzyme system is regarded as the acid (proton) pump within the stomach mucosa (for example, omeprazole [Prilosec®]).

GERD as related to Proton-pump Inhibitors