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Charcot-Marie-Tooth Disease as related to Duloxetine


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AR-CMT2; Charcot-Marie-Tooth disease, type 1; Charcot-Marie-Tooth disease, type 2; Charcot-Marie-Tooth disease, type 4; ... 

Cymbalta 

Charcot-Marie-Tooth disorder (CMT) is an inherited neurological disease characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand, and forearm, and a mild loss of sensation in the limbs, fingers, and toes. The first sign of CMT is generally a high arched foot or gait disturbances. Other symptoms of the disorder may include foot bone abnormalities such as high arches and hammer toes, problems with hand function and balance, occasional lower leg and forearm mus...

Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. ...


Charcot-Marie-Tooth Disease as related to Duloxetine


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November 23, 2009


Page Updated: January 17, 2009
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