Connective Tissue Disease; Dupuytren's Contracture; Mixed Connective Tissue Disease; PXE 

A chronic disorder marked by hardening and thickening of the skin. Scleroderma can be localized or it can affect the entire body (systemic).

Connective Tissue Disease: Autoimmune diseases involving a disorder of the body's connective tissues.

Scleroderma as related to Connective Tissue Disorders