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Huntington's Disease as related to Adrenoleukodystrophy


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Huntington disease; Huntington//'s chorea; Huntington//'s disease; Progressive Chorea, Chronic Hereditary (Huntington) 

ALD 

Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cann...

Adrenoleukodystrophy (ALD) is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, an insulating membrane that surrounds nerve cells in the brain. People with ALD accumulate high levels of saturated, very long chain fatty acids (VLCFA) in the brain and adrenal cortex because they do not produce the enzyme that breaks down these fatty acids in the normal manner. ALD has two subtypes. The most common is the X-linked form (X-ALD), which involves an...


Huntington's Disease as related to Adrenoleukodystrophy


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November 29, 2009


Page Updated: January 17, 2009
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