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ACH; Achondroplasia; Chondrodystrophia; Chondrodystrophy syndrome; Congenital osteosclerosis; Dwarf, achondroplastic; Os... | |
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Pituitary dwarfism is a condition of growth retardation characterized
children and adolescents may present with neurological symptoms such as headaches vomiting and problems with vision The patient may also have symptoms of double vision Symptoms such as truly bizarre and excessive drinking behaviors polydipsia and sleep disturbances may be common
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mouse and a mouse with a genetic form of dwarfism df ef A novel positional cloning was used to define the responsible gene as one encoding a novel homeodomain protein referred to as Prop 1 which exhibits pituitary specific expression The basis of the Prop 1 mutation is a failure of asymmetric division of perilumenal cells of the anterior pituitary gland leading
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Click on image to view larger version Fig 3 B4B2A5m mice dwarfism is GH and T3 T4 independent A B X Gal detection of lacZ expression in pituitary 200 µm section A and whole thyroid gland B of adult B4B2lacZ mice

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