Travoprost		Glaucoma
Travatan		OAG

Pictures

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Travoprost 0 004 timolol 0 5 ophthalmic solution contribution of elements intent to treat Figure 4 The future of glaucoma management will likely include combination products as the additive effects of medications in different classes have been shown to be more effective than

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at 100 of visits at 4PM Figure 1 Travoprost has demonstrated longer lasting IOP control than other glaucoma agents which is particularly beneficial given the difficulty in establishing and maintaining compliance

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Extended IOP control travoprost vs latanoprost study C 01 103 Figure 2 Among the prostaglandin analogues travoprost maintains its IOP lowering effects longer after instillation and has been shown to achieve a greater IOP reduction at all time points

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Travoprost therapy results in a narrow range of diurnal IOP fluctuation Figure 3 Patients with the largest diurnal fluctuation in IOP are at significant risk of progression Travoprost has been shown to limit diurnal fluctuation to a range of less than 4 mm Hg

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for ophthalmic use was latanoprost 0 005 solution Xalatan® This drug was followed by travoprost 0 004 solution Travatan® and bimatoprost 0 03 solution Lumigan® Figure 18 Ophthalmic prostaglandins for glaucoma treatment From left to right latanoprost 0 005 Xalatan® travoprost 0 004 Travatan® and bimatoprost 0 03 Lumigan® Images

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of the class and therefore is the most clinically useful It is our most often prescribed chronic care drug Travoprost Of the prostaglandins travoprost most closely mimics all the characteristics of latanoprost We like the clear bottles

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James L Fanelli O D A 38 year old white female presented as a new patient seeking a second opinion about her recently diagnosed glaucoma Her last doctor prescribed Travatan travoprost Alcon one drop O D h s

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a monocular therapeutic trial and reevaluate the patient in two to three weeks Once a therapeutic benefit has been established continue with bilateral therapy if indicated Travoprost Of the prostaglandins travoprost most closely mimics all the characteristics of latanoprost Just as the obsession with refrigeration of latanoprost has been moderated so too we predict

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efficacy and must be administered twice a day so it s not appropriate for first line therapy For that reason I ll focus on the prostamide and the prostaglandin analogues in this discussion ASSESSING EFFICACY The graph to the right shows the results of phase III clinical trials comparing the efficacy of bimatoprost latanoprost and travoprost with the nonselective beta blocker

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As it turned out subpopulation analyses showed that response to bimatoprost was still significantly better for both of these groups throughout the diurnal curve during the entire 6 months Replacing Two Medications with Travoprost 0 004 S T A R T Study of Travatan as Replacement Therapy an open label multicenter prospective 4 week trial was conducted to evaluate the IOP

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As it turned out subpopulation analyses showed that response to bimatoprost was still significantly better for both of these groups throughout the diurnal curve during the entire 6 months Replacing Two Medications with Travoprost 0 004

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TRAVATAN Z® Ophthalmic Solution PDF TRAVATAN® Ophthalmic Solution TRAVATAN® solution travoprost ophthalmic solution 0 004 is a prescription eye drop used to reduce elevated intraocular pressure IOP in patients suffering from open angle glaucoma

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Dr Ritch He concluded that the bulk of the evidence from clinical trials indicates that all three agents lower IOP equally on average The issue of whether some patients get further IOP

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Dr Wilensky GBE is a potent antioxidant and in various studies has been shown to protect against free radical damage and lipid peroxidation In addition GBE has been shown to preserve

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Dr Singh Since SLT causes less structural change in the angle than ALT there is the notion that SLT in contrast to ALT might be more repeatable That potential advantage however

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Figure 5 Alcon s Travatan Dosing Aid the first monitoring device for glaucoma medication will soon be available Specifically used for delivering travoprost the Travatan Dosing Aid helps

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96 indicated they wanted more data on RGPs and the role this modality plays in myopia management NEW APPROVALS Glaucoma Drug to Benefit African Americans and others The FDA has approved Alcon s travoprost ophthalmic solution 0 004 Travatan for lowering IOP in patients with open angle glaucoma or

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In the travoprost circadian study design patients IOP measurements were taken every 4 hours for 36 hours and at 60 hours and 84 hours Photo courtesy of Harvey DuBiner MD In a

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