Not Signed In - Pictures
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PANSS and haloperidol showed a 76 decrease in PANSS When these first episode patients were followed over time there was less relapse with risperidone 42 compared to haloperidol 55 Medication Adherence McEvoy and colleagues7 9 conducted a 1 year trial of the comparative efficacy of olanzapine quetiapine and risperidone in treating first episode schizophrenia
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only in the first episode This may have to do with quetiapine s relatively low affinity for the dopamine D 2 receptor whereby a higher dose is required for sufficient dopamine blockade In other studies findings have shown that a dose ~50 lower than that used in multi episode psychosis may be ideal for first episode patients Slide 17 8 10 22 23 Several side effects
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only in the first episode This may have to do with quetiapine s relatively low affinity for the dopamine D 2 receptor whereby a higher dose is required for sufficient dopamine blockade In other studies findings have shown that a dose ~50 lower than that used in multi episode psychosis may be ideal for first episode patients Slide 17 8 10 22 23 Several side effects
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65 quetiapine 88 and ziprasidone 69 In the intolerability group risperidone 63 appeared superior to quetiapine 81 olanzapine 80 and ziprasidone 78 Slide 13 4 In the tolerability pathway the drugs also differed statistically from one another in time to discontinuation Olanzapine and risperidone demonstrated longer time to discontinuation for
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label treatments aripiprazole clozapine fluphenazine olanzapine perphenazine quetiapine risperidone ziprasidone or a combination of two of these antipsychotics Slide 1 1 5 Limitations Generalizability The CATIE study aimed to be representative of general clinical practice Participants were eligible regardless of comorbid substance abuse or use of
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rates were better for olanzapine 67 Risperidone also demonstrated a better discontinuation rate 64 in contrast to quetiapine 84 and ziprasidone 77 Slide 12 4 The tolerability pathway was also analyzed separately among patients who discontinued phase I for lack of efficacy versus those who discontinued phase I due to drug intolerability In the
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1 Slide 4 2 Perphenazine had the highest discontinuation rate due to EPS 8 compared to ziprasidone 4 risperidone and quetiapine 3 each and olanzapine 2 Slide 5 2
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