Pantoprazole		GERD
Protonix		Acid Reflux; Gastroesophageal Reflux; Gastroesophageal Reflux (GERD); Gastroesophageal Reflux Disease; Gastroesophageal ...

Pictures

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and persistent nighttime heartburn can be a symptom of erosive Gastroesophageal reflux disease or erosive GERD in which sores develop in the lining of the esophagus 8 ADVERSE SIDE EFFECTS of PROTONIX

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bulges into the chest cavity through an opening in the diaphragm hiatus The diaphragm is a sheet of muscle that separates the stomach cavity from the chest cavity What are the symptoms of GERD Heartburn is the most common symptom of GERD It feels like a burning chest pain right behind the breastbone Pain

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the stomach Reflux means to back up or flow backwards GERD is a condition in which acid bile and partially digested food in the stomach back up into the esophagus

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PROTONIX has become the number one oral proton pump inhibitor PPI in hospitals Here are some of the reasons PROTONIX is used to treat erosive GERD gastroesophageal reflux disease a

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CONCLUSION In patients with moderate to severe GERD treatment with pantoprazole 40 mg and esomeprazole 40 mg led to low symptom load values within 4 weeks of treatment

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PROTONIX helps to control NIGHTTIME heartburn and other symptoms associated with erosive GERD daytime heartburn acid reflux and difficulty swallowing Most patients who have erosive GERD

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Protonix Pantoprazole Description autotranslated Common uses This medicine is a proton pump inhibitor PPI used to treat ulcers gastroesophageal reflux disease GERD erosive esophagitis or Zollinger Ellison syndrome This

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rapidly than the others Pantoprazole is available intravenously although I see no advantages vs orally Esomeprazole may be in its 40 mg tablet slightly more potent than the others Slide 34 Choosing Between PPIs for Treating GERD What are the factors you need to consider when you choose between PPIs in treating GERD Do they relieve symptoms Do they heal esophagitis

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Images

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have unacceptable recurrence rates over 50 up to 80 similarly for cisapride It s only if we maintain these patients with omeprazole or lansoprazole that we can maintain healing of the EE Slide 19 Rabeprazole in Long Term Maintenance of Healed Erosive GERD We ve seen the introduction of 3 additional PPIs rabeprazole pantoprazole and esomeprazole There are similar data for

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Congresses

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is 3A4 some 2C19 Lansoprazole is 3A4 to get induction of 1A Rabeprazole is evenly distributed and pantoprazole with 2C19 but it s followed immediately by sulfate conjugation Slide CYP2C19 Metabolism Helicobacter pylori Eradication I wanted to talk to you about differences in metabolism of these enzymes The best example is CYP2C19 Mutations are quite

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PPI pantoprazole and this is IV pantoprazole given in patients There is a quick suppression of acid and this is maintained throughout the period of treatment Slide IV PPI + Endoscopy Slide Endoscopic Hemostasis With all this information in mind in Hong Kong we have embarked on a study looking critically into the use of IV proton pump inhibitors in addition to endoscopy

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the enteric coating is removed and then the PPI is absorbed The unprotonated PPI transverses the membrane goes to the secretory canaliculus where it can be activated It s a prodrug Slide Activation of Substituted Benzimidazoles If we look at this more specifically with the schematic shown here for pantoprazole we have the unproteinated form that is readily absorbed

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sucralfate and H2 blocker The pneumonia incidence was not significantly different among the 3 groups but there was also no significant reduction of GI bleeding among the 3 treatment arms Slide IV Pantoprazole for Patients in the ICU There are a few anecdotal experiences of using proton pump inhibitors to prevent ICU patients from developing GI bleeding but there are no

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