Fluoxetine		Eating Disorders
Prozac; Prozac Weekly; Sarafem		Anorexia; Binge Eating; Bulimia; Eating Disorder

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Prozac ineffective in maintaining gains in anorexia

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Eating Disorders Most trials had fewer than 50 subjects and were negative Space precludes a discussion of all these trials this paper focuses on those that have evaluated antidepressants Table 1 The double blind randomized controlled trial by Kaye et al 2001 is notable for its long duration and placebo controlled evaluation of fluoxetine Prozac previously found to

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trials such as the use of Olanzapine for treating children under 13 or Fluoxetine for relapse prevention Sheena s Place A Psychosocial Model for People with Eating Disorders Anne Kerr is the Program Director of Sheena s Place a charitable organization established in 1994 in memory of Sheena Carpenter to provide the kind of support that she did not receive

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Prozac Prozac is used to treat depression obsessive compulsive disorder OCD and eating disorders Prozac belongs to a group of drugs called selective serotonin reuptake inhibitors SSRIs

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a larger treatment effect among children than adolescents Single site versus multi site did not impact outcome study by week by treatment group interaction F1 521 =0 01 P = 917 Table 3 shows additional outcomes including baseline and exit scores for the CDRS R total score and CDRS R mean factor scores for both age groups by treatment Change scores are also

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in the children than in the adolescents The effect size for change in CDRS R total score was medium for children effect size 0 71 but small for adolescents effect size 0 39 Examining factor scores children showed greater improvement with fluoxetine than placebo on all factors while adolescents showed greater improvement with fluoxetine than placebo on only

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P = 001 but not adolescents 32 6 vs 21 7 P = 128 Remission rates were relatively low over the 8 week trial for both age groups even within the fluoxetine condition Table 4 To examine changes of suicidality in these age groups we examined CDRS R suicide item 13 Table 5 For purposes of these analyses a score of >3 was identified as presence of suicidal

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also had a extended length of illness 22 6±24 1 weeks vs 17 3±20 3 weeks P = 036 and more severe depression at baseline based on CDRS R 59 5±11 1 vs 53 2±9 2 P < 001 Baseline demographic and clinical characteristics were also similar for both treatment groups within each age group However within the child subgroup those on fluoxetine were more

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fluoxetine 11 5 and placebo 13 2 P = 730 No differences were found between children and adolescents on worsening of suicidality 9 7 children 14 3 adolescents P =0 294

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PROZAC Fluoxetine is used to treat depression bulimia an eating disorder obsessive compulsive disorders OCD and severe symptoms of premenstrual syndrome premenstrual dysphoric disorder PMDD

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Fluoxetine Prozac is used to treat depression some eating disorders obsessive compulsive disorder bothersome thoughts that won t go away and the need to perform certain actions over and

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32 33 Fluoxetine was used as an active comparator to venlafaxine ER during the acute and continuation phases patients on fluoxetine stayed on fluoxetine during both maintenance phases During each of the two maintenance phases patients who were responders to venlafaxine were rerandomized to either venlafaxine or placebo for 12 months The primary objective of each

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2 while those receiving fluoxetine continued on fluoxetine This article describes the rationale and design for the PREVENT study and subsequent reports will provide the study results Why Study Recurrent Depression Recurrences of MDD are common 3 Rates of recurrence have been estimated at 40 within 1 year of the index depressive episode and 85 within 15 years 4

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Remeron Fluoxetine is used to treat depression bulimia an eating disorder obsessive compulsive disorders OCD and severe symptoms of premenstrual syndrome premenstrual dysphoric

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in CYP2D6 and that a number of widely used antidepressants such as bupropion fluoxetine and paroxetine at their usual therapeutic doses can produce phenocopies of CYP2D6 deficiency Based on positron emission tomography PET scans D2 receptor occupancy exceeding 80 is associated with an increased risk of extrapyramidal symptoms EPS whereas 50 to 70 is needed

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fluvoxamine indinavir itraconazole ketoconazole nelfinavir nefazodone and ritonavir CYP1A2 by fluvoxamine and omeprazole and CYP2C by fluoxetine fluvoxamine and omeprazole 8 Contrary to popular belief bupropion does inhibit CYP2D6 At 300 mg day it produces almost the same magnitude of effect as paroxetine or fluoxetine which is significant because bupropion

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