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Tamsulosin		Enlarged prostate
Flomax		Benign Prostatic Hyperplasia; BPH; BPH Benign Prostatic Hyperplasia; Enlarged Prostate/Benign Prostatic Hyperplasia

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one week of treatment with tamsulosin 0 4 mg day P<0 001 At the end of the trial 70 of patients achieved ≥25 decrease in symptoms with tamsulosin compared with 51 with placebo 1 Significant improvement in Qmax was observed within 4 to 8 hours after a single dose of tamsulosin 0 4 mg P=0 05 compared with placebo and was maintained throughout the 13 weeks of the

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from baseline defined as ≥25 decrease in symptom score For the 159 patients who had a potential 6 years of tamsulosin experience the mean improvements from baseline are shown below 1 Symptom improvement was significant and lasted for the duration of the study The number of patients who responded clinically was consistent during the first five years 71 6 74 5 and was

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orthostatic changes in systolic and diastolic blood pressure and pulse rate with tamsulosin treatment did not meaningfully change from baseline throughout the course of the clinical trial See the efficacy results from the Six Year Efficacy and Safety Trial 527 2

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of tamsulosin patients receiving 0 4 mg day or placebo at an incidence numerically higher than that in the placebo group during the two 13 week trials are summarized in the table below 2 3 Discontinuation rates due to tamsulosin treatment 0 4 mg day were comparable to those of placebo and no patients stopped therapy because of abnormal ejaculation 2 Notably there were

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Flomax Flomax Tamsulosin is an alpha blocker that is used to improve symptoms associated with an enlarged prostate

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to histologic evidence of smooth muscle hyperplasia as well as stromal and epithelial proliferation of the prostate Often BPH manifests anatomically as benign prostatic enlargement BPE 1 View the animated version of this graphic The clinical manifestations of BPH and attendant BPE ie lower urinary tract symptoms LUTS are closely related to the degree of bladder outlet