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Acid Reflux; Gastroesophageal Reflux; Gastroesophageal Reflux (GERD); Gastroesophageal Reflux Disease; Gastroesophageal ... |
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H2 blockers and proton pump inhibitors are two drugs that can treat heartburn
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©2007 Publications International Ltd Over the counter H2 blockers seem to help about half of heartburn sufferers
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Tums H2 Blockers H2 blockers also called H2 receptor antagonists are medicines that reduce the amount of acid the stomach produces by blocking one important producer of acid histamine2
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shows that there s just no comparison the PPIs are wonderful drugs and far superior to the H2 blockers They work great Not only that but they work no matter how severe the erosive GERD Slide H2RA vs PPI in Erosive GERD When H2 blockers were approved for use for erosive GERD in 1989 the doses were quite high the frequency of administration was quite often and the
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dyspeptic symptoms like regurgitation belching bloating satiety and nausea These symptoms may be relieved although less than heartburn by treating them with antireflux treatment Slide 13 Efficacy of PPI vs Placebo in Maintaining Remission in NERD What about the use of H2 blockers Many of you come from areas under managed care and as a result they provide you
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Promotility agents are used to improve GERD symptoms for patients with slow gastric emptying They speed digestion which prevents acid from staying in the stomach too long They may also be used for patients with GERD when therapy with H2 blockers or PPIs does not work
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of patients who were still in remission was about 34 Obviously those who received omeprazole 20 mg showed more success in maintaining remission than those who received H2 blockers Slide 14 Life Table Analysis of Time to Discontinuation of On Demand Therapy With Esomeprazole 20 mg or Placebo This is another study that looks at esomeprazole This is a life table
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involved a major operation But now we have medication to help us define these extra esophageal manifestations to find out how serious the disease could be and how we could treat it Slide H2RA vs PPI in Erosive GERD This is a meta analysis with Chiba the first author looking at H2 blockers and PPIs and again this is erosive GERD Very importantly you ll see
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in 84 The PPIs because of their physiological action to completely turn off gastric acid secretion result in much higher symptomatic improvement and healing rates than H2 blockers Slide 15 Recurrence Common in Patients With Healed Erosive Esophagitis GERD is a chronic disorder If one treats a cohort of patients either with an H2 blocker or with a PPI and it
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Slide 16 H2RAs in GERD Tolerance With Continued Use Another problem potentially with the H2 blockers is that as they are continued to be dosed patients may develop tolerance to the
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at a time we had three PPIs on the market four H2 blockers 52 of people said they were amenable to something new They weren t happy Most did not have erosive GERD they had symptoms Slide GERD Iceberg This is the GERD iceberg We primarily study these patients up here at the tip of the iceberg and the mid portion of the iceberg The patients we see the people who we
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