Diabetes		Insulin glargine
Blood Sugar; Diabetes Mellitus; Non-Insulin Dependent Diabetes Mellitus; Type II Diabetes		insulin glargine [rDNA origin]; Lantus

Pictures

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The international journal Diabetic Medicine says that type 2 diabetics may achieve the targeted blood sugar levels It may be done with the help of insulin glargine It is once daily basal

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Lantus and syringe

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profiles after subcutaneous injection of insulin aspart insulin lispro insulin glulisine regular insulin NPH insulin insulin detemir and insulin glargine

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of time overnight at BG < 70 mg dL vs 34 7 of time overnight spent by MDI with long acting insulin glargine patients 19 Insulin pump therapy reduces the risk of severe lows vs mdi 17 REAL reduction in morning hyperglycaemia

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Type 1 Diabetes Patients Can Temporarily Switch From Continuous Subcutaneous Insulin Infusion With Insulin Aspart to Basal Bolus Therapy With Insulin Aspart adn Insulin Glargine view poster

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↑ Comparison of Levemir insulin detemir NPH Isophane Insulin Lantus insulin glargine

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My nightly regimen

On the left Lantus glargine insulin On the right Fragmin a blood thinning anticoagulant

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Note PAIR IN average daily dose of insulin 0 62 0 37 U kg for Humalog Mix75 25 vs 0 57 0 37 U kg glargine P< 001 PAIR PI average daily dose of insulin 0 42 0 20 U kg for Humalog

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compared to glargine In those who did not achieve their treatment goals the predinner glucose levels were lower in the glargine treated individuals That reached statistical significance Slide 19 Symptomatic Hypoglycemia in Patients Treated With Insulin Glargine HOE 901 and NPH Insulin Overall hypoglycemic events were reduced in the glargine treated patients all episodes

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Slide 14 Basal Insulin Glargine When given in the abdomen the arm or the leg the absorption profiles of glargine are essentially identical which is an advantage to many patients Slide 15 Insulin Pharmacodynamics NPH vs Ultralente vs Glargine vs CSII Of the basal insulins that we have available let s compare their pharmacodynamics This is taken from a paper

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a smooth and peakless profile that has reproducible and predictable effects and reduces the risk of hypoglycemia particularly in nocturnal hypoglycemia and that can be given once a day Slide 13 Insulin Glargine A New Long Acting Insulin Analogue We have come a long way toward developing a basal insulin and the newest of the basal insulins is glargine a long acting

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has a later and a slightly broader peak and glargine has probably the smoothest profile of the insulins here and closely approximates what s observed with continuous infusion of insulin Slide 16 Plasma Glucose Concentrations After SC Injection of NPH Ultralente Glargine and CSII When one gives an SC injection of the insulin and then measures glucose ultimately one can

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® and Insulin Lispro Humalog® From Continuous Subcutaneous Insulin Infusion CSII With Insulin Lispro A Randomized Open Label Study Using Continuous Glucose Monitoring System CGMS view poster JSH

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slowly whereas the effect of NPH and Ultralente is shorter and glucose levels rise earlier after administration Again continuous infusion of insulin is shown in the red as a comparison Slide 17 HbA1c Concentrations and Insulin Doses in Patients Treated With Insulin Glargine HOE 901 or NPH Now what about some studies looking at the use of glargine as compared to NPH in

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New Insulin Now Available The new long acting Lantus or glargine insulin is now available at pharmacies in the US Lantus is distinct in that it offer a prolonged non peaking action time Lantus was compared to other long acting insulins NPH and Ultralente NPH peaks in 4 to 6 hours and is gone in 15 to 16 hours as shown by the blue line to the right Lantus action is

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Angela was born to be wild She also has type 2 diabetes and pills alone weren t giving her the control she needed So she asked her doctor about LANTUS® insulin

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when given subcutaneously and is slowly absorbed from an SC depot allowing for a gradual release of insulin from the injection site and a more smooth and peakless long acting profile Slide 14 Basal Insulin Glargine When given in the abdomen the arm or the leg the absorption profiles of glargine are essentially identical which is an advantage to many patients

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glucose FPG of under 120 mg dL when either NPH or glargine was used The HbA1c was significantly lower in those who did achieve their treatment goal for the FPG of less than 120 mg dL Slide 18 Diurnal Blood Glucose Profile in Patients Reaching and Not Reaching FBG Target of Less Than 120 mg dL Glargine vs NPH What is interesting is what we see with some of the glucose

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states If the medicine is cloudy or has particles in it throw the vial away and get a new one Lantus uses the color purple to help identify the product see photo below Also see

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