Diabetes		Insulin Lispro
Blood Sugar; Diabetes Mellitus; Non-Insulin Dependent Diabetes Mellitus; Type II Diabetes		Humalog

Pictures

Insulin Needle

2 Then he has to dial up the amount of insulin

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Insulin Injection

3 He then has to inject himself All this is typically 3 or more times a day I think

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Insulin

Some of the kit needed because of this particular curse that god s placed on him

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Blood glucose Meter

First this friend has to check his glucose level

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The rapid acting analogues only provide prandial insulin while regular insulin contributes to both prandial and basal insulinemia B=breakfast L=lunch

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therapy with Lantus as a basal insulin while using the same fast acting insulin to cover carbs Both studies found a unit for unit conversion of basal dosage to Lantus View Aspart study View Lispro study

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and Metabolic Effects A team from Temply University School of Medicine compared insulin aspart NovoLog and insulin lispro Humalog and found them to be essentially identical in effect View the poster

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is still active and provides the patient a final suggested dose which the patient may activate or override B=breakfast L=lunch S=supper HS=bedtime

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profiles after subcutaneous injection of insulin aspart insulin lispro insulin glulisine regular insulin NPH insulin insulin detemir and insulin glargine

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NPH insulin regimen which was then combined with either regular or insulin lispro injections As the graph shows those taking insulin lispro plus NPH had more stable blood glucose levels Figure 7 Blood glucose levels of patients with type 1 diabetes taking NPH and either insulin lispro or regular human insulin Adapted from Lalli et al Diabetes Care 1999 22 468 477

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in patients with type 2 diabetes insulin lispro was also associated with an overall reduction in hypoglycemic events and a significant reduction between midnight and 6 am P < 001 30 Figure 9 The distribution of hypoglycemic episodes throughout the day in patients with type 1 diabetes taking insulin lispro compared with those taking regular human insulin Adapted from

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of nocturnal hypoglycemia Figure 5 shows 30 fewer severe hypoglycemic episodes among patients with type 1 diabetes taking insulin lispro than among those taking regular human insulin 25 Figure 5 Insulin therapy and severe hypoglycemic episodes in patients with type 1 diabetes Data from Brunelle et al Diabetes Care 1998 21 1726 1731 25 Hypoglycemia in Children and

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pumping by using MDI therapy with Lantus as a basal insulin while using the same fast acting insulin to cover carbs Both studies found a unit for unit conversion of basal dosage to Lantus View Aspart study View Lispro study

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Rotating sites For your insulin to work best it s important to use a different location for each injection This is called site rotation and involves following a regular pattern as

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levels all day long Figure 8 36 Nighttime glycemic control may be improved by decreasing the pre dinner insulin lispro dose by 20 and increasing the bedtime dose of NPH by 25 40 Figure 8 Plasma glucose concentrations of patients with type 1 diabetes taking regular human insulin insulin lispro and insulin lispro plus NPH Levels of the control subjects are shown on

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resulted in improved postprandial glycemic control similar overall glycemic control and less nocturnal hypoglycemia in patients with type 2 diabetes Figure 10 illustrates the changes 47 Figure 10 The changes in plasma glucose and insulin among patients with type 2 diabetes taking NPH insulin 30 70 insulin and Mix 25 insulin lispro The control group is also represented

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the findings from a study by L Heinemann and colleagues 31 which showed that the greater postprandial blood glucose decreases were achieved by insulin lispro than by regular human insulin Figure 6 Comparison of blood glucose levels in patients with type 1 diabetes following regular and insulin lispro injections after a carbohydrate rich meal From Heinemann et al Diabet Med

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What happens when you have diabetes

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Humalog in insulin pumps Humalog is approved for use in external insulin pumps It was the first rapid acting insulin approved for use in external insulin pumps and 65 of patients

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