Schizophrenia		Quetiapine
Schizoid personality disorder; Schizotypal personality disorder		Seroquel

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Welcome to the SEROQUEL Information website

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of Seroquel tablet can be prescribed depending on which country you are in The name Seroquel and the strength is always written on the tablet Here are some examples of Seroquel tablets Doctors and pharmacists know which drugs can be taken simultaneously with Seroquel You should let your doctor know if you are taking any other drugs

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PANSS and haloperidol showed a 76 decrease in PANSS When these first episode patients were followed over time there was less relapse with risperidone 42 compared to haloperidol 55 Medication Adherence McEvoy and colleagues7 9 conducted a 1 year trial of the comparative efficacy of olanzapine quetiapine and risperidone in treating first episode schizophrenia

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for the treatment of schizophrenia and other psychotic syndromes It produces less extrapyramidal side effects hyperprolactinmia and agranulocytosis than other neuroleptics 1 2 Fig 1 Chemical structures of QTP QTP H QTP SF and QTP ND In vitro experiments indicated CYP3A4 was the main isoenzyme involved in quetiapine sulfoxidation and N and O

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The optimal dose of SEROQUEL for patients with schizophrenia is approximately 600 mg day 8 16 SEROQUEL initial titration Example dosing schedule

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c Quetiapine 50 mg d Olanzapine 20 mg Click here to view full size graphic

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Seroquel 100 mg yellow round film coated

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65 quetiapine 88 and ziprasidone 69 In the intolerability group risperidone 63 appeared superior to quetiapine 81 olanzapine 80 and ziprasidone 78 Slide 13 4 In the tolerability pathway the drugs also differed statistically from one another in time to discontinuation Olanzapine and risperidone demonstrated longer time to discontinuation for

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label treatments aripiprazole clozapine fluphenazine olanzapine perphenazine quetiapine risperidone ziprasidone or a combination of two of these antipsychotics Slide 1 1 5 Limitations Generalizability The CATIE study aimed to be representative of general clinical practice Participants were eligible regardless of comorbid substance abuse or use of

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Leistungsfähigkeit Die durchschnittliche Dosierung bei den Patienten die nach acht Wochen die Studie erfolgreich abgeschlossen hatten betrug 626mg Seroquel bzw 6mg Risperidon Zhong K X Sweitzer D E Hamer R M Comparison of quetiapine and ris peridone in the treatment of schizophrenia a randomized double blind flexible dose 8 week study J Clin Psychiatry

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rates were better for olanzapine 67 Risperidone also demonstrated a better discontinuation rate 64 in contrast to quetiapine 84 and ziprasidone 77 Slide 12 4 The tolerability pathway was also analyzed separately among patients who discontinued phase I for lack of efficacy versus those who discontinued phase I due to drug intolerability In the

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e g risperidone olanzapine amisulpiride quetiapine clozapine etc Psychosocial Therapies including behavioural therapy family therapy group therapy social skills training

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1 Slide 4 2 Perphenazine had the highest discontinuation rate due to EPS 8 compared to ziprasidone 4 risperidone and quetiapine 3 each and olanzapine 2 Slide 5 2

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only in the first episode This may have to do with quetiapine s relatively low affinity for the dopamine D 2 receptor whereby a higher dose is required for sufficient dopamine blockade In other studies findings have shown that a dose ~50 lower than that used in multi episode psychosis may be ideal for first episode patients Slide 17 8 10 22 23 Several side effects

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