Schizophrenia		Ziprasidone
Schizoid personality disorder; Schizotypal personality disorder		Geodon

Pictures

gatewayHeader jpg

Patient Summary of Information | Prescribing Information Welcome to the GEODON pronounced Gee uh don Web site

---

Geodon jpg

Geodon Review Geodon is used to treat severe mental disorders like schizophrenia which are characterized by distorted thoughts perceptions and emotions Geodon helps manage

---

0906 RTM Slide 13 jpg

65 quetiapine 88 and ziprasidone 69 In the intolerability group risperidone 63 appeared superior to quetiapine 81 olanzapine 80 and ziprasidone 78 Slide 13 4 In the tolerability pathway the drugs also differed statistically from one another in time to discontinuation Olanzapine and risperidone demonstrated longer time to discontinuation for

---

0906CNS RTM1 jpg

label treatments aripiprazole clozapine fluphenazine olanzapine perphenazine quetiapine risperidone ziprasidone or a combination of two of these antipsychotics Slide 1 1 5 Limitations Generalizability The CATIE study aimed to be representative of general clinical practice Participants were eligible regardless of comorbid substance abuse or use of

---

0906 RTM Slide 12 jpg

rates were better for olanzapine 67 Risperidone also demonstrated a better discontinuation rate 64 in contrast to quetiapine 84 and ziprasidone 77 Slide 12 4 The tolerability pathway was also analyzed separately among patients who discontinued phase I for lack of efficacy versus those who discontinued phase I due to drug intolerability In the

---

0906CNS RTM3 jpg

1 Slide 4 2 Perphenazine had the highest discontinuation rate due to EPS 8 compared to ziprasidone 4 risperidone and quetiapine 3 each and olanzapine 2 Slide 5 2

---

globalFooter gif

---

Oldham figsmall jpg

and there was no further evidence of hyponatremia or respiratory difficulties Her antibiotics were discontinued She was transferred to the inpatient psychiatric unit for further treatment Discussion This case is different than a number of the previously reported cases of ziprasidone overdose for a few reasons First this was a ziprasidone only overdose that resulted in a

---

Geodon jpg

showed long term efficiency in patients that suffer from schizophrenia who did not respond to other drug According to a clinical study published in the Journal of Psychiatry Loebel and his colleagues studied patients with a diagnosis of treatment resistant schizophrenia who had been treated for one year with ziprasidone an atypical antipsychotic The study involved 62 patients

---

geodon jpg

Generic Geodon ZIPRASIDONE is an antipsychotic used to treat mental and emotional disorders such as schizophrenia or bipolar disorder It may also be used to treat conditions as

---

0906CNS RTM6 jpg

minimal side effects in order to be effective If a drug is not both efficacious and tolerable the patient will not continue taking it and it therefore is not considered effective The case has been made that all antipsychotics are equal in efficacy However that notion is based on data comparing drug to placebo The CATIE study compared antipsychotic drugs against

---

0906 RTM Slide 11 jpg

3 However the numbers of patients enrolled in each of the treatment arms were small so there were no significant differences observed in treatment discontinuation due to intolerability Some issues to consider are that clozapine was given open label so the patients receiving it knew that they were taking clozapine Patients in this pathway who were receiving blinded

---

0906 RTM Slide 8 jpg

in which the patient had a relatively low clinical severity of illness rating On this measure olanzapine was superior to the other medications with an average of ~3 months Slide 8 2 Real World Patients Importance of Treating the Individual All patients have past experiences of how well they functioned on one medication over another which ones they tolerated better

---

geodonjf7 png

Geodon ziprasidone Geodon is used in the treatment of the crippling mental disorder known as schizophrenia Researchers believe that it works by opposing the action of serotonin and dopamine two of the brain s

---

0906 RTM Slide 7 jpg

showed greater overall effectiveness with the median time to all cause discontinuation being longer at 9 2 months compared to 3 5 5 6 months observed with the other medications Successful treatment in phase I was defined as the number of months in treatment in which the patient had a relatively low clinical severity of illness rating On this measure olanzapine

---

0906CNS RTM4 jpg

Although the overall discontinuation rate of 74 appears high it really is not surprising as patients were not actually dropping out of the study per se Rather patients were generally

---

0906CNS RTM2 jpg

4 was due to weight gain metabolic effects 4 was because of EPS 1 8 was due to sedation and 4 9 was attributable to other reasons related to intolerability Slide 2 2 Discontinuation rates due to intolerability were fairly low at 15 but there were some important differences noted among the drugs Discontinuation was highest with olanzapine 19

---

geodone jpg

customer satisfaction However Geodon is not for everyone please consult your physician before taking this or any other drug Geodon is the brand drug name for Ziprasidone Geodon is used to treat certain mental mood disorders schizophrenia or manic mixed episodes associated with bipolar disorder It may be used after other medications have not been

---

pill geodon 60 jpg

not actual size not actual size

---

0906 RTM Slide 9 jpg

delivery The NNT for steroids versus placebo in prevention of fetal respiratory syndrome is 11 thus one case of respiratory distress syndrome is avoided for every 11 persons treated Thus the global NNT discontinuation rate that encompasses efficacy tolerability and adherence ranges between 6 and 11 patients Slide 10 NNTs for discontinuation due to loss of

---