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Sign Up to see the image without SAMPLE View Demo plates Visual Mnemonic Alkylating Agents Nitrosoureas Mechlorethamine Cyclophosphamide Ifosfamide Carmustine Lomustine Cisplatin Carboplatin Procarbazine Dacarbazine Copyright 2004 2005
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an abundant supply of deoxythymadylate for the synthesis of DNA Therefore the vulnerability of these cells to the inhibition of dTMP synthesis can be exploited in cancer therapy The rational for 5 fluorouracil 5 FU was to block DNA synthesis by inhibiting the biosynthesis of dTMP by virtue of its close structural analogy to uracil Fluorine being the
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B Anti metabolites pyrimidine antagonists 5 Fluorouracile Pyrimidine Antagonist Cancer is a group of diseases characterized by abnormal and uncontrolled cell division One important approach to antitumor agents is the design of compounds with structures related
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larger than that of the H atom 1 20 A Therefore 5 fluorouracil is a fluorinated pyrimidine analogue which stops cell proliferation by blocking DNA synthesis and RNA processing Fluorouracil is converted in vivo into fluorodeoxyuridylate F dUMP This analog of dUMP irreversibly inhibits thymidylate synthase after acting as a normal substrate through part
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