Interferon Alfa-2b

Intron A

Pictures

image6sm jpg

Picture 6 Pegylated interferon alfa 2b plus ribavirin therapy for chronic hepatitis C From Manns et al Lancet 2001 Sep 22 358 9286 958 65 Click to view larger image BIBLIOGRAPHY

---

interferon image jpg

antiproliferative and antiviral activities which enables its broad therapeutic applications in cancer and infectious diseases Manufacturing process

---

figur2 gif

women were most at risk for severe anemia Hemoglobin was reduced by more than 25 from baseline in one third of patients Sulkowski MS et al AASLD 2000 Abstract Figure 2 Source Sulkowski MS Wasserman R Ball L et al Changes in hemoglobin during therapy with interferon alfa 2b plus ribavirin in interferon alfa naïve and interferon alfa experienced

---

figure4 gif

who develop anemia on ribavirin interferon alfa 2b therapy 51st Annual Meeting of the American Association for the Study of Liver Diseases AASLD Dallas October 2000 Abstract Source Wasserman R Brau N Hassanein T et al Once weekly epoetin alfa increases hemoglobin and decreases ribavirin dose reductions among HCV infected patients who develop anemia on

---

inatisolinterferonalfabinjectioninjectable jpg

INTERFERON ALFA 2B Injection Injectable

---

iinterferonalfabrecombinant jpg

Interferon alfa 2b recombinant

---

348 jpg

Date 1 11 2005 Pegylated Interferon Alfa 2b Effective for Chronic Hepatitis B Approximately one third of patients with chronic hepatitis B become negative for hepatitis B e antigen HBeAg when treated with pegylated interferon alfa 2b PegIntron Schering Plough a

---

HalfLIfe 1 gif

called albumin interferon alfa 2b alb IFN is a single polypeptide molecule that combines the therapeutic activity of interferon alpha with the long half life of human serum albumin Study Design Design Randomized open label active control Population IFN treatment naive genotype 1 Conducted at 82 sites in Canada Europe Israel and Australia

---

image5lg jpg

The treatment of hepatitis C has evolved over the years see Image 5 It is discussed as follows Recombinant interferon IFN alfa 2b was the first drug approved by the US Food and Drug Administration FDA for use in the treatment of

---

inf alfa jpg

Interferon alfa 2b recombinant

---

figure3 gif

r HuEPO permitted maintenance of minimal ribavirin dosing at an average ribavirin dose of 982 mg day compared to 678 mg day Wasserman R et al Hepatology 2000 32 368 Figures 3 and 4 Source Wasserman R Brau N Hassanein T et al Once weekly epoetin alfa increases hemoglobin and decreases ribavirin dose reductions among HCV infected patients who develop anemia on

---

mrihead jpg

Protocols for Children with Brain Tumors 02 C 0193 A Phase II Study of Pegylated Interferon Alfa 2b Peg Intron in Children with Diffuse Pontine Gliomas Principal

---

preinter 2 gif

Author s Conclusions This is the first prospective randomized trial comparing dose reduction with growth factor supplementation using a wide spectrum of weight based PEG IFN alfa 2b

---

image5sm jpg

Click to view larger image Picture 5 Evolution of the treatment for hepatitis C virus infection Click to view larger image Picture 6 Pegylated interferon alfa 2b plus ribavirin therapy for chronic hepatitis C From Manns et al Lancet 2001 Sep 22 358 9286 958 65

---

10P046 jpg

10P046 100 mcg 0 5 ml vial 現行藥物外觀 中文名 派樂能

---

mole 1 gif

systemic circulation of recombinant interferon alpha 2b and improve its therapeutic activity The long half life of the drug ~150 hours or 6 days supports dosing every 2 or 4 weeks Dose selection for combination Phase 2 studies were based on the Phase 2a study were doses of 900 and 1200 mcg administered 14 days apart showed 1 Mean antiviral reduction of 3 2 log IU

---

table2 3 gif

---

image004 png

---

image1lg jpg

have chronic liver disease which may progress to cirrhosis and hepatocellular carcinoma Chronic infection with HCV is one of the most important causes of chronic liver disease see Image 1 Currently chronic hepatitis C is the most common indication for orthotopic liver transplantation in the United States HCV is a spherical enveloped single stranded RNA virus

---

meanAge 5 gif

In total 103 patients were randomized to treatment and 93 received at least 1 dose of PEG IFN RBV Figure 2

---