Insulin glargine

insulin glargine [rDNA origin]; Lantus

Pictures

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The international journal Diabetic Medicine says that type 2 diabetics may achieve the targeted blood sugar levels It may be done with the help of insulin glargine It is once daily basal

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insulin

Lantus and syringe

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profiles after subcutaneous injection of insulin aspart insulin lispro insulin glulisine regular insulin NPH insulin insulin detemir and insulin glargine

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of time overnight at BG < 70 mg dL vs 34 7 of time overnight spent by MDI with long acting insulin glargine patients 19 Insulin pump therapy reduces the risk of severe lows vs mdi 17 REAL reduction in morning hyperglycaemia

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↑ Comparison of Levemir insulin detemir NPH Isophane Insulin Lantus insulin glargine

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Many patients find the basal insulins do not last the entire 24 hours and they give the insulin twice daily B=breakfast L=lunch S=supper HS=bedtime Regarding long acting insulin analogues clinical trials have demonstrated lower fasting glucose levels and less nocturnal hypoglycemia with insulin

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Byetta injections combined with oral medication resulted in better blood sugar control weight loss and a lower incidence of hypoglycemia in type 2 diabetics than insulin glargine treatments A new study conducted by Amylin Pharmaceuticals Inc and Eli Lilly Co finds that BYETTA exenatide injections appear to be better for type 2 diabetics than the traditional insulin

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そのため一日１回の注射でピークがなく24時間安定して効果が持続するインスリン製剤が待ち望まれていました

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Type 1 Diabetes Patients Can Temporarily Switch From Continuous Subcutaneous Insulin Infusion With Insulin Aspart to Basal Bolus Therapy With Insulin Aspart adn Insulin Glargine view poster

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With its introduction giving a single bedtime dose of Glargine insulin and metered doses of inhaled insulin prior to each meal snack may further facilitate intensive control Fig 2 Mean serum insulin concentration in non diabetic subjects after subcutaneous injection 0 2 U kg of human insulin Aspart and regular human insulin o at

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Human Insulin Crystals Article disclaimer

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compared to glargine In those who did not achieve their treatment goals the predinner glucose levels were lower in the glargine treated individuals That reached statistical significance Slide 19 Symptomatic Hypoglycemia in Patients Treated With Insulin Glargine HOE 901 and NPH Insulin Overall hypoglycemic events were reduced in the glargine treated patients all episodes

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Slide 14 Basal Insulin Glargine When given in the abdomen the arm or the leg the absorption profiles of glargine are essentially identical which is an advantage to many patients Slide 15 Insulin Pharmacodynamics NPH vs Ultralente vs Glargine vs CSII Of the basal insulins that we have available let s compare their pharmacodynamics This is taken from a paper

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a smooth and peakless profile that has reproducible and predictable effects and reduces the risk of hypoglycemia particularly in nocturnal hypoglycemia and that can be given once a day Slide 13 Insulin Glargine A New Long Acting Insulin Analogue We have come a long way toward developing a basal insulin and the newest of the basal insulins is glargine a long acting

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has a later and a slightly broader peak and glargine has probably the smoothest profile of the insulins here and closely approximates what s observed with continuous infusion of insulin Slide 16 Plasma Glucose Concentrations After SC Injection of NPH Ultralente Glargine and CSII When one gives an SC injection of the insulin and then measures glucose ultimately one can

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Note PAIR IN average daily dose of insulin 0 62 0 37 U kg for Humalog Mix75 25 vs 0 57 0 37 U kg glargine P< 001 PAIR PI average daily dose of insulin 0 42 0 20 U kg for Humalog

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slowly whereas the effect of NPH and Ultralente is shorter and glucose levels rise earlier after administration Again continuous infusion of insulin is shown in the red as a comparison Slide 17 HbA1c Concentrations and Insulin Doses in Patients Treated With Insulin Glargine HOE 901 or NPH Now what about some studies looking at the use of glargine as compared to NPH in

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New Insulin Now Available The new long acting Lantus or glargine insulin is now available at pharmacies in the US Lantus is distinct in that it offer a prolonged non peaking action time Lantus was compared to other long acting insulins NPH and Ultralente NPH peaks in 4 to 6 hours and is gone in 15 to 16 hours as shown by the blue line to the right Lantus action is

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in a very similar fashion Lantus is the most popular basal insulin and it has a fairly flat action profile over a 24 hour period Here is a graph of the Lantus Glargine action profile As you can see it takes about 6 hours for lantus to get up to full strength but if it is injected every day it provides a consistent level of action over the 24 hour cycle Some people

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