Sumatriptan Oral

Imitrex

Pictures

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SUMATRIPTAN Oral Tablet

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100 mg Results for oral sumatriptan 100 mg were consistent between trials and those for two hour headache response are shown in Figure 1 Figure 1 Headache response at two hours Table 1 Results for oral sumatriptan 100mg

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response sustained for 24 hours with no additional analgesic was 6 7 5 0 to 9 9 in 1 632 patients in four trials Oral sumatriptan 50 mg Figure 1 Headache response at two hours Table 1 Results for oral sumatriptan 50mg

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The clinical lesson to be learned from this trial is that if one triptan doesn t work for a patient it is important not to abandon the whole class of agents but to try a different drug Table 4 Sumatriptan Nonresponders Reprinted with permission from Mathew NT Kailasam F Meadors L et al Treatment of oral sumatriptan nonresponders with 5 mg zolmitriptan and 10 mg

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specific therapies Nonspecific treatments include analgesics antinausea medications and sedatives Table 1 These therapies are effective for treating mild to moderate migraine pain Table 1 Nonspecific Headache Medications Specific acute care medications include dihydroergotamine DHE and the triptans sumatriptan rizatriptan zolmitriptan naratriptan eletriptan and

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Vasoconstriction of meningeal dural cerebral or pial vessels mediated via stimulation of vascular 5 HT1B receptors Sumatriptan was the first approved triptan for the acute treatment of migraine However due to the low bioavailability of sumatriptan oral tablets and the low patient acceptability of

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Table 2 Migraine Specific Rx Pharmacokinetics Table 3 Migraine Specific Rx Efficacy Differences in half life also have a clinical effect in terms of recurrence of headache Table 2 The half life of most of the available medications is

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Table 2 Migraine Specific Rx Pharmacokinetics Table 3 Migraine Specific Rx Efficacy Differences in half life also have a clinical effect in terms of recurrence of headache Table 2 The

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of migraine involves changes in vascular dilation neural activation and muscle spasm Currently it is believed that migraine occurs as a result of a 4 step process Figure 1 1 Figure 1 Neurovascular hypothesis of headache Step 1 A trigger be it physical chemical or psychological prompts a chemical change in the dorsal raphe and locus ceruleus leading to the

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have not been well studied which prohibits you from offering useful advice to your patients Table 5 quantifies the effectiveness of the nonmedication prescriptions that have been studied Table 5 Effectiveness of Nonmedication Prescriptions Headache education prevention and treatment Headache education is a critically important treatment for patients Such education does

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Figure 2 Choice of migraine therapy Figure 3 Choice of migraine therapy Figure 4 Choice of migraine therapy

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Figure 3 Choice of migraine therapy Figure 4 Choice of migraine therapy Patients who have frequent headache episodes are then categorized according to the severity of their headache Those who have mild to moderate headaches

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preventive therapy largely because if they re using acute care medications more than 3 or 4 days a week on a regular basis they are at risk for developing analgesic overuse headaches Figure 2 Choice of migraine therapy Figure 3 Choice of migraine therapy

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In actual clinical practice or in other clinical trials these frequency estimates may not apply as the conditions of use reporting behavior and the kinds of patients treated may differ Other events that occurred in more than 1 of patients receiving IMITREX Tablets and at least as often on placebo included nausea and or vomiting migraine headache hyposalivation

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