Dementia - Subcortical

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but may be severe This is typically a subcortical dementia It may antedate the motor findings Duration is about 5 15 years The underlying pathologic defect is damage and death of the dopaminergic pigmented neurons of the substantia nigra the cells of origin of the nigrostriatal pathway Grossly there is loss of pigmentation in substantia nigra

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Prof Otto Binswanger

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TauMapPSP GIF

is found in subcortical and cortical areas at the last stage of the disease when dementia is observed At the biochemical level we were not able to distinguish between PSP and CBD are they at the opposite

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Figure 4 Axial FDG PET images of patient with late stage AD There is severe parietal and temporal hypometabolism in these regions with sparing of only sensorimotor visual and subcortical

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Therefore Tau aggregates in PSP and CBD have a specific pattern type II different from Alzheimer s disease type I and from Pick s disease Type III The upper tau doublet 64 69 so characteristic is found in subcortical and cortical areas at the last stage of the disease when dementia is observed

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THE 3R AND 4R CLASSIFICATION The upper tau doublet so characteristic is found in subcortical and cortical areas at the last stage of the disease when dementia is observed

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Media file 2 T2 weighted MRI shows ventricular enlargement and large areas of hyperintense signal in the subcortical white matter of both frontal lobes Media type MRI

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son de pequeño tamaño inferior a 1 5 cm y de localización subcortical Se presentan tanto en ganglios basales como en tálamo sustancia blanca o tronco cerebral Fig 4

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lagunas y leucoencefalopatía se ha conocido como encefalopatía subcortical arteriosclerótica24 y en muchos casos ha recibido el discutido epónimo de enfermedad de Binswanger25 La presencia de lesiones de la sustancia blanca o de leucoencefalopatía isquémica en pacientes con demencia había sido ya resaltada por Binswanger y Alzheimer Desde el punto de

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The upper tau doublet so characteristic is found in subcortical and cortical areas at the last stage of the disease when dementia is observed At the biochemical level we were not able to distinguish between PSP and CBD are they at the opposite ends of the same spectrum However there are significant differences in the

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8890t4 GIF

lower scores at the 1 month postoperative period were revealed only when Fisher s test was applied and that no difference was discerned with Scheffé s and the Bonferroni tests DISCUSSION Extensive neuropsychological studies in patients with PD and other basal ganglia disorders have revealed a syndrome of subcortical dementia that relates to cognitive

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so characteristic is found in subcortical and cortical areas at the last stage of the disease when dementia is observed At the biochemical level we were not able to distinguish between PSP and CBD are they at th opposite ends of the same

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