Sickle Cell Anemia

Hb S disease; Hemoglobin S Disease; Herrick's anemia; SCD

Pictures

14x15sickle jpg

= different amino acid UCA > UUA ser to leu Sickle Cell Anemia a mis sense mutation SCA pleiotropy another point mutation blood disease thalassemia

---

shortened finger jpg

a similarly high population percentage of sickle cell carriers Evidence even suggests that perhaps this trait of missing or amputated fingers has been going on from the prehistoric ages Another correlation between social habits and sickle cell anemia is some tribes eating habits In 1983 Durham found a strong correlation between the high percentage of carriers in

---

7433W jpg

---

sickle cell 01 jpg

and organs Blocked blood vessels can cause pain serious infections and organ damage Normal and Sickled Red Blood Cells Figure A shows normal red blood cells flowing freely in a blood vessel The inset image shows a cross section of a normal red blood cell with normal

---

r7 sicklecells jpg

Sickle cell anemia Sickle cell anemia Normal red blood cells are round In sickle cell anemia some red blood cells become deformed so they look like a sickle used to cut wheat These unusually shaped cells give the disease its

---

sickle cell jpg

---

hdc 0001 0003 0 img0235 jpg

ethnic background be tested for the presence of the HbS at birth Babies with sickle cell disease are often given antibiotics to prevent infections Before this screening became common One normal and one sickled red blood cell side by side under the electron microscope photographed at 18 000 times actual size

---

BHG01HE02F01 GIF

Figure 1 Sickled Cells Sickle cell anemia is a type of anemia named after a characteristic change in shape that occurs in the red blood cells

---

Bossed Skull jpg

skull that sometimes come with the sickle cell anemia trait and disease are beautiful or that they confer some association with the spirits of the dead such as shortened fingers or toes Even those not afflicted with the trait tend to cut off fingers or mutilate their children in some way to be more protected from the early death that a previous child has suffered

---

sickle gif

Pleiotropy occurs when alleles at a single locus may have effects on two or more traits A classic example is the effect of the mutant allele at the beta globin locus that gives rise to sickle cell anemia

---

sickle cell 02 gif

shows how two parents with sickle cell trait pass along the sickle cell gene Inheritance Pattern for Sickle Cell Trait The illustration shows how sickle cell genes are inherited A person inherits two copies of the hemoglobin gene one from each parent A normal

---

sicklecellanemia jpg

---

hemoglobin picture jpg

Hemoglobin is the most important component of red blood cells It is composed of a protein called heme which binds oxygen In the lungs oxygen is exchanged for carbon dioxide Abnormalities

---

hdc 0001 0003 0 img0236 jpg

when clumping of sickled RBCs in the blood vessels obstructs the normal flow of blood depriving various tissues and organs of oxygen The first crises usually appear in early childhood The inheritance pattern for the sickle cell gene HbS Crises may be brought on by respiratory infection by a loss of body fluids from vomiting or diarrhea by situations where the

---

sickle cell anemia jpg

Sickle Cell Anemia

---

siccells jpg

SCD Remember Sickle Cell anemia is just one type of Sickle Cell Disorder Other known SCD is listed under Types Click here for diagram

---

inheriting sickle cell genes jpg

---

sickle2005 jpg

Stamping Out Sickle Cell Disease Walk a thon 2005 Registration The Stamping Out Sickle Cell Disease Walk a thon 2005 will be held Saturday June 4 2005 at the FCCJ Downtown Campus Registration is free and begins at 8 a m Walk begins at

---

250px Sickle cell 01 jpg

---

Inheritance Traits jpg

in the fact that a person with the disease lacks no normal alleles while the carrier has a good allele that keeps the sickle cell hemoglobin from polymerizing under normal conditions Carriers under extreme de oxygenated conditions will exhibit similar characteristics to persons homozygous for the sickle cell anemia allele Usually the HbS hemoglobin traits are not

---