NOTCHing Up Heart Development

Mon, 05 Feb 2007 12:00 AM EST

... Defects in the heart and/or blood vessels (cardiovascular defects) in both humans and mice can result from mutations in any one of a number of genes encoding proteins that are part of the Notch signaling cascade. However, it has not been determined which cell type these mutations affect to cause these cardiovascular defects. [click link for full article] ...