Low Dose And High Dose Ketoconazole Demonstrate Similar Outcomes In Patients With Androgen-Independent Prostate Cancer

... Patients on androgen deprivation therapy (ADT) for prostate cancer (CaP) eventually progress with a rising PSA. Definitions of androgen-independence vary, but usually include a documented castrate level of testosterone and failure of second-line hormonal therapy. One second-line therapy is ketoconazole, a broad-spectrum azole anti-fungal drug that inhibits gonadal and adrenal steroid synthesis. [click link for full article] ...