Drug Combo May Reduce Protease Inhibitor-related Hardening Of The Arteries

... Researchers may have found a way to decrease the risk of hardening of the arteries that accompanies the long-term use of protease inhibitors, a class of drugs that has emerged as the most effective treatment against HIV. When mice were given a nucleoside reverse transcriptase inhibitor (didanosine or d4T) and a protease inhibitor in combination, it prevented hardening of the arteries often associated with long-term use of protease inhibitors alone. ...