Recent Blog Posts

View Post: Potential Impact of UAW, GM Agreement on Other Companies Examined
20 Nov 2009 by tdomf_ac833  
Among the subtypes of multiple endocrine neoplasia type 2, type 2A is the most common form, followed by familial medullary thyroid cancer. Type 2B is relatively uncommon, accounting for about 5 percent of all cases of multiple endocrine ...
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View Post: Arquivos Brasileiros de Endocrinologia & Metabologia - Splicing ...
20 Nov 2009
Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma Oncogene. ... Cancer Lett. 2001;163(2):143-56. [ Links ]. 41. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA. High prevalence of BRAF mutations in thyroid cancer:genetic evidence for constitutive activation of the RET/PTCRAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. ...
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View Post: Cell - KIF26A Is an Unconventional Kinesin and Regulates GDNF-Ret ...
12 Nov 2009
Germline mutations in the proto-oncogene are responsible for two unrelated neural crest disorders: Hirschsprung disease, a congenital absence of the enteric nervous system in the hindgut, and multiple endocrine neoplasia type 2, a dominantly inherited cancer syndrome. Moreover, somatic rearrangements of are causally involved in the genesis of papillary thyroid carcinoma. The receptor tyrosine kinase encoded by the gene acts as the subunit of a multimolecular complex that ...
View Blog: CELL - http://www.cell.com/current

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View Post: Medical, Nursing & Health - Books and Stuff: Atlas of Clinical ...
7 Nov 2009 by Blog Owner  
... there have been numerous advances in our understanding of the etiology of endocrine tumors, the ability to identify some endocrine tumors such as medullary thyroid cancer, multiple endocrine neoplasia (MEN) type II, and MEN type I ...
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View Post: Genetic testing in pheochromocytoma
10 Oct 2009 by MaryO  
These include: multiple endocrine neoplasia type 2, von Hippel-Lindau syndrome, neurofibromatosis type 1 and familial paraganglioma. MEN2 is due to mutations of the RET proto-oncogene. In addition to medullary thyroid cancer and primary ...
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View Post: Pheochromocytoma and Papillary Carcinoma in a Man With ...
18 Aug 2009
The ret proto-oncogene, shown to be rearranged in human papillary thyroid cancers, has been mapped to 10q11.2 near the locus for MEN 2, indicating a genetic predisposition.11. PHEOCHROMOCYTOMA AND MENINGIOMA ... Medullary carcinoma of the thyroid gland. Cancer. 1975;35:695-704. 10. Khairi MR, Dexter RN, Burzynski NJ, et al. Mucosal neuroma, pheochromocytoma and medullary thyroid carcinoma: multiple endocrine neoplasia type 3. Medicine (Baltimore). 1975;54:89-112. ...
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