Recent Blog Posts

View Post: New analysis shows SYMBICORT® improved airflow obstruction in ...
9 Nov 2009
Lower respiratory tract infections, including pneumonia, have been reported following the inhaled administration of corticosteroids. In two placebo-controlled SYMBICORT COPD clinical studies, pneumonia did not occur with greater incidence in the SYMBICORT 160/4.5 group, compared with ... This finding with salmeterol may apply to formoterol (a long-acting beta2-adrenergic agonist), one of the active ingredients in SYMBICORT (see WARNINGS in full Prescribing Information). ...
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View Post: FDA accepts BLA for IV-AAT, a treatment for alpha-1 antitrypsin ...
4 Aug 2009
Phase 2b study of oglemilast for treatment of Chronic Obstructive Pulmonary Disease (COPD). August 19, 2009. Forest Laboratories and Glenmark Pharmaceuticals announced top-line results from a Phase 2b dose range-finding study of oglemilast in patients with Chronic Obstructive Pulmonary Disease (COPD). Intal Inhaler discontinued. August 04, 2009. King Pharmaceuticals has decided to discontinue the manufacturing of Intal Inhaler (cromolyn sodium inhalation aerosol). ...
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View Post: Advair Diskus (Fluticasone Propionate) Drug Information: Uses ...
19 Jun 2008
Data from a large placebo-controlled US study that compared the safety of salmeterol (SEREVENT® Inhalation Aerosol) or placebo added to usual asthma therapy showed an increase in asthma-related deaths in patients receiving salmeterol ..... To be enrolled, all of the patients had to have had a COPD exacerbation in the previous 12 months. In this trial, 88% of the patients treated with ADVAIR DISKUS and 86% of the patients treated with salmeterol reported an adverse event. ...
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View Post: USPharmacist.com > Management Strategies in Stable COPD
26 Jan 2009
Inhaled beta2 agonists have a fairly rapid onset of action. Short-acting beta2 agonists such as albuterol have a duration of action of 4 to 6 hours, while long-acting beta2 agonists (salmeterol, formoterol, and arformoterol) have a duration of ..... In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone. An 85-day multicenter trial. COMBIVENT Inhalation Aerosol Study Group. Chest. 1994;105:1411-1419. ...
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View Post: Long-Acting Bronchodilator Therapy for the Treatment of Chronic ...
1 Dec 2008 by Chen, A. M, Bollmeier, S. G, Finnegan, P. M  
The first inhaled LABA, salmeterol, was initially approved by the Food and Drug Administration (FDA) in 1994, with the addition of an approval for maintenance treatment of bronchospasm associated with COPD in 2002.23 Much of the literature ... aerosols containing sympathomimetics, as these agents had been used in a large proportion of patients.33,34 Today, the GOLD guidelines maintain that studies have found no association between the use of β2-agonists in COPD and ...
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View Post: Video: COPD Landmark Trial UPLIFT Proves Tiotropium Sustains Lung ...
6 Oct 2008
Improved health outcomes in patients with COPD during 1 year's treatment with tiotropium. Eur Respir J 2002; 19:209-216. 7. Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary ... Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58: 399-404. Video: http://www.prnewswire.com/mnr/uplift/35106/ ...
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View Post: AstraZeneca PLC Submits an sNDA for SYMBICORT(R) for COPD ...
30 Apr 2008
(1) Some estimates also suggest that 12 million more people have COPD but are undiagnosed.(1) COPD is a term referring to two serious lung diseases -- emphysema and chronic bronchitis -- that cause a person's airways to become inflamed ... Data from a large placebo-controlled U.S. study compared the safety of another long-acting beta2-adrenergic agonist (salmeterol) or placebo added to usual asthma therapy showed an increase in asthma-related deaths in patients receiving ...
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View Post: 05.10.2008 COPD landmark trial UPLIFT - Boehringer Ingelheim News -
4 Oct 2008
A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J. 2002; 1:217-224. 7 Celli B, ZuWallack R, Wang S, et al. Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD ... 9 Brusasco V, Hodder R, Miravitlles M, et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58: 399-404. ...
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View Post: RESPIRATORY DRUGS
28 Oct 2009
Beta-2 Selective Agonists  Long acting:  Salmeterol, formoterol  Given b y inha lat io n  DOA: 12 ho urs o r m or e Intera c t with co rtico st ero ids to im pro ve asthm a c on tro l    Salmeterol-fluticasone ... quarternary ammonium derivative of atropine Tiotro pium – structural analog of ipratr opium, approv ed for COPD, permits once daily dosing Delivered b y aerosol (metered dose inhaler/nebulizer) Slightly less effective than beta agonist     ...
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View Post: Asthma - Getting the Most out of Dry Powder Inhaler for Asthma and ...
31 Oct 2008
New York, NY April 3, 2008 -- Proper technique is the key to benefiting from dry powder inhalers (DPIs) that treat chronic obstructive pulmonary disease (COPD) and asthma. But data presented at the annual meeting of the American College ... Compared with aerosol metered dose inhalers, DPIs are considered "user-friendly": They don't require coordination between breathing in and squeezing the inhaler to release medication, and DPIs rely on your breath rather than chemical ...
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