Recent Blog Posts

View Post: Thioguanine
13 Oct 2009 by 思源致远  
The amount of Thioguanine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your ...
View Blog: WHEN DRINKING WATER, REMEMBER THE SPRING - http://daisiyuan.blogspot.com/

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View Post: Arch Dermatol -- Abstract: Thioguanine Nucleotides and Thiopurine ...
15 Jun 2009 by el-Azhary, RA, Farmer, SA, Drage, LA, Rogers,...  
Limited disease required less 6-thioguanine, with a mean of 145.3 pmol/8 x 108 RBCs. Longitudinal induction of thiopurine methyltransferase activity was observed during treatment. Patients with recalcitrant disease showed higher ...
View Blog: Archives of Dermatology current issue - http://archderm.ama-assn.org/

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View Post: Patent Law Blog (Patently-O): Mayo v. Prometheus: Medical Methods ...
28 Oct 2009 by Dennis Crouch  
Claim 1 of the '302 patent adds additional detail including identifying the active ingredient (6-thioguanine), the diagnosis (a GI disorder), and the predetermined thresholds (e.g., 230 pmol of drug per 8108 red blood cells). ...
View Blog: Patent Law Blog (Patently-O) - http://www.patentlyo.com/patent/

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View Post: The Volokh Conspiracy » Blog Archive » Mayo Collaborative Servs. v ...
28 Oct 2009 by Eugene Volokh  
wherein the level of 6-thioguanine less than about 230 pmol per 8x108 red blood cells indicates a need to increase the amount of said drug subsequently administered to said subject and wherein the level of 6-thioguanine greater than ...
View Blog: The Volokh Conspiracy - http://volokh.com/

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View Post: <i>Prometheus Laboratories</i>: Federal Circuit Applies <i>In re ...
27 Sep 2009
The district court then concluded that the claims wholly preempt the correlations between concentrations of selected metabolites (e.g., 6-thioguanine) and therapeutic efficacy or toxicity in the patients, and thus did not claim ...
View Blog: All Articles on Martindale.com - http://www.martindale.com/all/legal-articles.htm

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View Post: DNA Mismatch Repair Initiates 6-Thioguanine-Induced Autophagy ...
22 Feb 2007 by Zeng, X., Yan, T., Schupp, JE, Seo, Y.,...  
Purpose: We investigate the roles of DNA mismatch repair (MMR) and p53 in mediating the induction of autophagy in human tumor cells after exposure to 6-thioguanine (6-TG), a chemotherapy drug recognized by MMR. ...
View Blog: Clinical Cancer Research recent issues - http://clincancerres.aacrjournals.org/

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View Post: Mutagenic and Cytotoxic Properties of 6-Thioguanine, S6 ...
22 Aug 2008 by Yuan, B., Wang, Y.  
Thiopurine drugs, including 6-thioguanine (SG), 6-mercaptopurine, and azathioprine, are widely employed anticancer agents and immunosuppressants. The formation of SG nucleotides from the thiopurine prodrugs and their subsequent ...
View Blog: Journal of Biological Chemistry current issue - http://www.jbc.org/

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