Temozolomide

Temodar

View Post: Brain and Central Nervous System Tumors Clinical Trial ...
10 Nov 2009
Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high energy x-rays to kill tumor cells. ...
View Blog: Clinical Trials Updates During the Last 7 Days - http://clinicaltrialsfeeds.org/clinical-trials/r...

View Post: Acquired Resistance to Combination Treatment with Temozolomide and ...
23 Oct 2009 by Liu, X., Han, EK, Anderson, M., Shi, Y.,...
ABT-888 potentiates the activity of DNA-damaging agents such as temozolomide (TMZ) in a variety of preclinical models. We report here the generation of HCT116 cells resistant to treatment with TMZ and ABT-888 (HCT116R cells). ...
View Blog: Molecular Cancer Research current issue - http://mcr.aacrjournals.org/

View Post: Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen ...
1 Oct 2009 by Quinn, JA, Jiang, SX, Reardon, DA, Desjardins,...
This phase I clinical trial conducted with patients who had recurrent or progressive malignant glioma (MG) was designed to determine the maximum tolerated dose (MTD) and toxicity of three different 5-day dosing regimens of temozolomide ...
View Blog: Neuro-Oncology current issue - http://neuro-oncology.dukejournals.org/

View Post: Loss of the Mismatch Repair Protein MSH6 in Human Glioblastomas Is ...
2 Apr 2007 by Cahill, DP, Levine, KK, Betensky, RA, Codd,...
Recently, inactivating mutations in the mismatch repair gene MSH6 were identified in two glioblastomas recurrent post-temozolomide. Because mismatch repair pathway inactivation is a known mediator of alkylator resistance in vitro, ...
View Blog: Clinical Cancer Research recent issues - http://clincancerres.aacrjournals.org/

View Post: Chemoradiotherapy of Newly Diagnosed Glioblastoma with Intensified ...
15 Oct 2009 by Markus Weiler, Christian Hartmann, Dorothee...
Purpose. To evaluate the toxicity and efficacy of chemoradiotherapy with temozolomide (TMZ) administered in an intensified 1-week on/1-week off schedule plus indomethacin in patients with newly diagnosed glioblastoma. ...
View Blog: International Journal of Radiation Oncology... - http://www.redjournal.org/inpress?rss=yes

View Post: Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT ...
2 Nov 2009 by admin
DOI 10.1007/s11060-009-0032-0 This retrospective series explores temozolomide monotherapy in elderly patients with primary CNS lymphoma (PCNSL) and severe comorbidities. In 17 patients (62–90 years old), the complete response rate was ...
View Blog: Neurosurgery Blog - http://www.neurosurgery-blog.com/

View Post: European medical advisory committee does not recommend approval of ...
16 hours ago
The BRAIN study was a US based open-label, multicentre, non-comparative phase II study including 167 patients with histologically confirmed GBM that had progressed following initial treatment with temozolomide and radiation. ...
View Blog: PharmaNews.eu - http://www.pharmanews.eu/component/content/frontpage

View Post: MALINGNANT GLIOMAS & ITS TREATMENT WITH CHEMOTHERAPEUTIC AGENT ...
20 Oct 2009 by admin
MALINGNANT GLIOMAS & ITS TREATMENT WITH CHEMOTHERAPEUTIC AGENT TEMOZOLOMIDE. Share/Save/Bookmark Tags: a-combined-incidence, anaplastic-astrocytoma, and-chemotherapy, cns, combined-incidence, median-reported, multiforme-and, Object, ...
View Blog: Cancer Research - http://cancerresearch.2kool4u.net/