Trastuzumab

Herceptin

View Post: Review: Mechanisms behind trastuzumab therapy for HER-2 positive ...
26 Nov 2009
The mechanisms of action of trastuzumab have not been fully elucidated. This paper reviews the data available to date and also discusses the impact of the mechanisms of action on clinical benefit. Specific topics covered include: ...
View Blog: NeLM - News - http://www.nelm.nhs.uk/en/NeLM-Area/News/

View Post: Trastuzumab Plus Anastrozole Versus Anastrozole Alone for the ...
18 Nov 2009 by Kaufman, Mackey, Clemens, Bapsy, Vaid,...
Trastuzumab Plus Anastrozole Versus Anastrozole Alone for the Treatment of Postmenopausal Women With Human Epidermal Growth Factor Receptor 2–Positive, Hormone Receptor–Positive Metastatic Breast Cancer: Results From the Randomized ...
View Blog: Journal of Clinical Oncology Current Issue - http://jco.ascopubs.org/

View Post: A phase I trial of paclitaxel and trastuzumab in combination with ...
10 Nov 2009 by Bekaii-Saab, TS, Roda, JM, Guenterberg,...
Our preclinical work showed a dramatic synergy between interleukin-12 (IL-12) and trastuzumab for stimulation of natural killer cell cytokine secretion. We aimed to determine the safety profile of IL-12 when given in combination with ...
View Blog: Molecular Cancer Therapeutics current issue - http://mct.aacrjournals.org/

View Post: {beta}1-Integrin Circumvents the Antiproliferative Effects of ...
11 Nov 2009 by Lesniak, D., Xu, Y., Deschenes, J., Lai,...
Notably, β1-integrin overexpression increased the phosphorylation of Akt-Ser473 and ERK1/2, thereby promoting survival and mitogenic signals to bypass the antiproliferative effects of trastuzumab. Our findings show that β1-integrin ...
View Blog: Cancer Research current issue - http://cancerres.aacrjournals.org/

View Post: In vitro activity of pertuzumab in combination with trastuzumab in ...
19 Nov 2009 by A D Santin
In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma. British Journal of Cancer advance online publication, November 17, 2009. doi:10.1038/sj.bjc.6605448. Authors: K El-Sahwi, ...
View Blog: British Journal of Cancer - AOP - nature.com... - http://feeds.nature.com/bjc/rss/aop

View Post: Study Finds It's Safe To Treat HER2-Positive Breast Cancer With ...
13 Nov 2009 by CancerCompass
However, a new study by researchers at Fox Chase Cancer Center reports that it may be safe to treat these patients with both Trastuzumab and adjuvant radiation therapy. The study will be presented today at the annual meeting of the ...
View Blog: Breast Cancer News Articles Provided by... - http://www.cancercompass.com/

View Post: TIME TO TUMOR PROGRESSION TO SELECT PATIENTS FOR TRASTUZUMAB USE ...
12 Nov 2009 by Dr. NICK
In a previous analysis performed on a cohort of 37 HER-2 positive metastatic breast cancer (MBC) patients treated with trastuzumab beyond progression, we found that a second trastuzumab-based therapy is associated with a considerable ...
View Blog: CANCER AND IMPORTANT MEDICAL NEWS - http://cancerology.blogspot.com/

View Post: Nonpegylated Liposomal Doxorubicin (TLC-D99), Paclitaxel, and ...
31 Dec 2008 by Cortes, J., DiCosimo, S., Climent, MA,...
Purpose: To determine the recommended dose, cardiac safety, and antitumor activity of nonpegylated liposomal doxorubicin (TLC-D99), paclitaxel, and the anti-HER-2 monoclonal antibody trastuzumab in patients with HER-2-overexpressing ...
View Blog: Clinical Cancer Research recent issues - http://clincancerres.aacrjournals.org/